Therapeutic Potential of Metabolites from Lactobacillus rhamnosus and Mares Milk in the Treatment of Dysbiosis
Kozhakhmetov S. Babenko D. Kozhakhmetova S. Tuyakova A. Nurgaziyev M. Nurgozhina A. Muhanbetganov N. Chulenbayeva L. Sergazy S. Gulyayev A. Aljofan M. Kushugulova A.
2022Hindawi Limited
BioMed Research International
2022#2022
Ulcerative colitis is an inflammatory bowel disease that forms ulcerations in the mucous membrane of the colon and rectum, in which gut microbiota plays a pivotal role in its pathogenesis. Agents modulating microbial dysbiosis caused by colitis can help in the remission of this disease. The current study describes the potential therapeutic effects of active metabolites from Lactobacillus rhamnosus and mares milk which have potential therapeutic values on the intestinal microbiota and proinflammatory cytokines. The analysis of the V1-V3 16S rDNA site revealed significant changes in the intestinal microbiome composition before and after treatment in the treated group compared to the positive control group that was treated with 5-aminosalicylic acid (5-ASA). So the effect of the study product on dextran sulfate sodium-induced dysbiosis was shown to be more potent than the positive control, 5-ASA. The level of proinflammatory cytokines also decreased under the influence of a biological product.
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National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
Kazakhstan Society of Researchers of Human Microbiome, Nur-Sultan, Kazakhstan
SaumalBioTech, Nur-Sultan, Kazakhstan
Innovation Center ArtScience, Nur-Sultan, Kazakhstan
National Center for Biotechnology, Nur-Sultan, Kazakhstan
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
National Laboratory Astana
Kazakhstan Society of Researchers of Human Microbiome
SaumalBioTech
Innovation Center ArtScience
National Center for Biotechnology
Department of Biomedical Sciences
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