Influence of pneumococcal conjugate vaccine 13 on upper respiratory tract microbial biodiversity in infants
Kozhakhmetov S. Aitenov Y. Ramazanova B. Koloskova Y. Burkutbayeva T. Yeraliyeva L. Mustafina K. Beglarova G. Yergazina M. Kushugulova А.
2021Society for Indonesian Biodiversity
Biodiversitas
2021#22Issue 115055 - 5060 pp.
Kozhakhmetov S, Aitenov Y, Ramazanova B, Koloskova Y, Burkutbayeva T, Yeraliyeva L, Mustafina K, Beglarova G, Yergazina M, Kushugulova A. 2021. Influence of pneumococcal conjugate vaccine 13 on upper respiratory tract microbial biodiversity in infants. Biodiversitas 22: 5055-5060. Pneumococcal disease and its associated mortality are burdens on the healthcare system. The intensive introduction of pneumococcal vaccines has provided robust control and infection management worldwide. The Pneumococcal Conjugate Vaccine (PCV) has been successfully employed in the national programs of many countries. However, no studies have yet analyzed the effect of pneumococcal vaccines on Central Asian populations. We investigated the effect of the pneumococcal vaccine on the nasopharyngeal microbiome of infants under the age of two years. Samples were collected from healthy patients as part of rout ine hospital check-ups, then subjected to high-throughput sequencing of the V1–V3 region of 16S rRNA for bioinformatics analysis. The obtained data were combined with the results of a previously published study (with matching criteria) to increase statistical power. No significant differences were found in vaccination status, sex or age. Nevertheless, the results demonstrated structural changes in t he microbiome of the upper respiratory tract under the influence of the PCV13 vaccine. The results of beta-diversity unweighted UniFrac distance measuring showed that the experimental groups differed in their qualitative (taxonomic) structure (p < 0.1). In the vaccinated group, the abundance of several symbiotic taxa was significantly decreased, including Streptococcus pneumonia.
Colonization , Microbiome , Streptococcus pneumonia , Upper respiratory tract , Vaccination
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Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Kabanbay Batyr Avenue 53, Block S1, Nur-Sultan, Kazakhstan
Kazakhstan Society of Researchers of Human Microbiome, Tawelsizdik 34, Z00T2C6, Nur-Sultan, Kazakhstan
Asfendiyarov Kazakh National Medical University. A05H2A6, Tole Bi Street 94, Almaty, Kazakhstan
Kazakh Medical University of Continuing Education Corporation. A15M0E6, Manasa Str. 34, Almaty, Kazakhstan
Ministry of Health of the Republic of Kazakhstan National Scientific Center of Phthisiopulmonology. A25H9G4, Bekkhozhin Str. 5, Almaty, Kazakhstan
Innovative Center ArtScience, Z00T3X6, 23-15 Str. 11, Nur-Sultan, Kazakhstan
Medical University of Astana, Z10K9D8, Beibitshilik str. 49А, Nur-Sultan, Kazakhstan
Laboratory of Human Microbiome and Longevity
Kazakhstan Society of Researchers of Human Microbiome
Asfendiyarov Kazakh National Medical University. A05H2A6
Kazakh Medical University of Continuing Education Corporation. A15M0E6
Ministry of Health of the Republic of Kazakhstan National Scientific Center of Phthisiopulmonology. A25H9G4
Innovative Center ArtScience
Medical University of Astana
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