Gut modulation of dysbiosis induced by dextran sulfate sodium
Kozhakhmetov S. Babenko D. Kozhakhmetova S. Tuyakova A. Nurgaziyev M. Nurgozhina A. Muhanbetganov N. Chulenbayeva L. Sergazy S. Gulyayev A. Tanabayev B. Saliev T. Kushugulova A.
August 2021Elsevier Ltd
Food Bioscience
2021#42
Inflammatory bowel disease is one of the serious burdens of clinical medicine and healthcare. This study investigated the potential of a biological product based on mares milk and metabolites of symbiotic microflora for modulation of intestinal microflora affected by dextran sulfate sodium (DSS)-induced dysbiosis. Symbiotic microflora was isolated from the stool of healthy volunteers. Lysates for the production of short-chain fatty acids of screened microorganisms were mixed with mares milk. The activity of the biological product was evaluated on the DSS model of induced colitis. Histological changes in the intestinal epithelium were determined. The structure of the microbiome was evaluated based on the analysis of 16S rRNA microbial sequences. Histological examination of rat intestinal tissues after application of the biological product showed reduced infiltration of granulocytes, macrophages, and lymphocytes. The results of sequencing demonstrated a decrease in the biological diversity of microbiota affected by colitis. The full recovery was observed after 21 days of the application of the biological product. The product induced the structural changes of the microbiome damaged by DSS. Likewise, the number of the pathogenic intestinal microflora was decreased Representatives of SCFA producing bacteria increased concentrations of genus Lactobacillus.
Biological product , DSS-Induced colitis , Gut microbiome , Microbial diversity , Rats
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Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Z05H0P9, Kazakhstan
Research Center Karaganda Medical University, Karagandy, M01K6T3, Kazakhstan
SaumalBioTech, Nur-Sultan, Z05H0K9, Kazakhstan
Innovative Center ArtScience, Nur-Sultan, Z11F5A9, Kazakhstan
South-Kazakhstan Medical Academy, Shymkent, X08F5X5, Kazakhstan
S.D. Asfendiyarov Kazakh National Medical University, Almaty, A05H2A6, Kazakhstan
National Center for Biotechnology, Nur-Sultan, Z05K8D5б, Kazakhstan
Nazarbayev University, Nur-Sultan, Z05H0P9, Kazakhstan
Laboratory of Human Microbiome and Longevity
Research Center Karaganda Medical University
SaumalBioTech
Innovative Center ArtScience
South-Kazakhstan Medical Academy
S.D. Asfendiyarov Kazakh National Medical University
National Center for Biotechnology
Nazarbayev University
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