Exploring the physicochemical interactions and loading strategies of mesoporous silicon dioxide nanoparticles for drug delivery
Kovtareva S.Y. Kopishev E.E. Zhang H. Filippov S.K.
March 2025Elsevier B.V.
European Journal of Pharmaceutics and Biopharmaceutics
2025#208
Mesoporous silica nanoparticles play an important role in drug delivery due to their high surface area, porous structure, tunable pore size, chemical stability and functionalization capability. Such properties make them a good candidate for drug encapsulation. However, molecular binding is another parameter that govern drug loading apart of pores’ structure and size. There is a lack of comprehensive reviews on that topic nowadays. This paper overviews the latest publications on the physicochemical aspects of the interaction of mesoporous silica nanoparticles with drugs. The review is focused primarily on a such parameters of the intermolecular binding between a drug and silica nanoparticle as a binding constant, enthalpy and entropy changes and experimental methods with the emphasis on the principles of thermodynamic parameters characterization. Such information would be very important for the development and optimization of drug delivery strategies based on mesoporous silica nanoparticles.
Adsorption , Drug delivery , Isothermal titration calorimetry (ITC) , Mesoporous silicon dioxide , Nanoparticles , Thermodynamic parameters
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Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov, Eurasian University National University, Astana, 010008, Kazakhstan
Pharmaceutical Sciences Laboratory, Åbo Akademi University, Turku, 20520, Finland
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, 20520, Finland
DWI – Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, Aachen, 52056, Germany
Department of Chemistry
Pharmaceutical Sciences Laboratory
Turku Bioscience Centre
DWI – Leibniz Institute for Interactive Materials
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