Comorbid Inducible Urticaria Is Linked to Non-Autoimmune Chronic Spontaneous Urticaria: CURE Insights

Kovalkova E. Fomina D. Borzova E. Maltseva N. Chernov A. Serdoteckova S. Weller K. Maurer M.
February 2024 American Academy of Allergy, Asthma and Immunology

Journal of Allergy and Clinical Immunology: In Practice
2024 #12 Issue 2 482 - 490.e1 pp.

Background: Patients with chronic spontaneous urticaria (CSU) can have comorbid inducible urticaria (CIndU). How comorbid CIndU affects patients and their CSU is largely unclear. Objective: To compare patients with CSU with and without comorbid CIndUs for differences in demographic features, clinical characteristics, and laboratory markers. Methods: We analyzed 708 patients with CSU of our Urticaria Center of Reference and Excellence enrolled in CURE, the chronic urticaria registry. CURE data collected until October 2022 were used to compare patients with and without comorbid CIndU for their demographic characteristics, disease onset, activity, impact, and control, as well as concomitant allergic and autoimmune diseases and laboratory parameters associated with autoimmune CSU. Results: Of 708 patients with CSU, 247 (35%) had comorbid CIndU. Compared with patients with standalone CSU, patients with CSU with comorbid CIndU were significantly younger, had earlier disease onset, longer disease duration, higher impact on quality of life, and a higher rate of concomitant allergic diseases. Moreover, patients with CSU with comorbid CIndU less often had features linked to autoimmune CSU such as angioedema, concomitant autoimmune diseases, eosinopenia, low levels of total IgE, and low total IgE combined with elevated anti–thyroid peroxidase IgG. Conclusions: Autoimmune CSU may be less common in patients with comorbid CIndU than without, and comorbid CIndU may point to autoallergic CSU.

Autoimmune chronic spontaneous urticaria , Chronic inducible urticaria , Non-autoimmune chronic spontaneous urticaria , Phenotypes , Retrospective analysis

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LEN Urticaria Center of Reference and Excellence (UCARE), Moscow City Research and Practical Center of Allergology and Immunology, Moscow Healthcare Department, City Clinical Hospital 52, Moscow, Russian Federation
Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Department of Pulmonology, Astana Medical University, Astana, Kazakhstan
Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Dermatology Division, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
LEN Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany

LEN Urticaria Center of Reference and Excellence (UCARE)
Department of Clinical Immunology and Allergology
Department of Pulmonology
Department of Dermatology and Venereology
Dermatology Division
LEN Urticaria Center of Reference and Excellence (UCARE)
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP

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