Optical modeling and design of Fabry–Perot interferometer sensors for detection of human skin cancer cells
Kovačević M.S. Marković V. Tosi D. Blanc W. Kovačević I. Kuzmanović L.
February 2026Elsevier GmbH
Optik
2026#345
This study presents a method for detecting cancer cells in human skin using a fiber-based sensor, referred to as a semi-distributed Fabry–Pérot interferometer (SDI FP sensor). The sensor employs a multimirror Fabry–Pérot structure formed between a single-mode cleaved fiber tip and a high-scattering fiber, whose core is doped with magnesium silicate nanoparticles, placed in contact with the three principal skin layers: epidermis, dermis, and hypodermis. For the first time, human skin is represented as a four-mirror Fabry–Pérot interferometer, with epidermal refractive index and thickness varying in the presence of cancer cells. First, the reflected spectrum of healthy skin tissue is modeled in the infrared wavelength range. Next, alterations in the reflected spectrum are analyzed in the presence of cancer cells, considering their distribution within each skin layer individually. The results reveal distinct shifts in spectral peaks and valleys between healthy and cancerous tissues, demonstrating the potential of the proposed approach for noninvasive detection of cancer cells across different skin layers. Additionally, a more sophisticated model was considered in which the epidermal refractive index varies randomly due to the presence of cancer cells, reflecting the realistic nonuniform distribution of cancer cells within the epidermal tissue. The proposed model provides a solid theoretical foundation for subsequent experimental validation.
Cancer cells , Fabry-Perot interferometer , Human skin , Optical fiber sensors
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Univeristy of Kragujevac, Faculty of Science, Department of Physics, Kragujevac, Serbia
Nazarbayev University, School of Engineering and Digital Sciences, Astana, 010000, Kazakhstan
National Laboratory Astana, Laboratory of Biosensors and Bioinstruments, Astana, 010000, Kazakhstan
Université Côte d′Azur, CNRS, INPHYNI, France
University of Belgrade, Faculty of Medicine, Belgrade, Serbia
University of East Sarajevo, Faculty of Medicine, Foča, Bosnia and Herzegovina
Univeristy of Kragujevac
Nazarbayev University
National Laboratory Astana
Université Côte d′Azur
University of Belgrade
University of East Sarajevo
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026