Digestive system and severe acute respiratory syndrome coronavirus 2: New era of microbiome study and gastrointestinal tract manifestations during the coronavirus disease-19 pandemic
Kossumov A. Mussabay K. Pepoyan A. Tsaturyan V. Sidamonidze K. Tsereteli D. Supiyev A. Kozhakhmetov S. Chulenbayeva L. Dusmagambetov M. Pignatelli M. Zhumadilov Z. Marotta F. Kushugulova A.
10 January 2021Scientific Foundation SPIROSKI
Open Access Macedonian Journal of Medical Sciences
2021#9676 - 682 pp.
The main topic of this review article is the study of gastrointestinal disorders that were accompanying the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although SARS-CoV-2 primarily causes lung infection through binding to angiotensin-converting enzyme 2 (ACE2) receptors, intestinal epithelial cells, especially enterocytes of the small intestine, also express ACE2 receptors. Viral RNA and viral particles can be observed in feces for more than 30 days. It is also known that a respiratory viral infection causes disturbances in the gut microbiota. Diets, environmental factors, and genetics play an important role in the formation of the gut microbiota, which can affect the immune system. The diversity of the gut microbiota diminishes with age, which means that the fact that coronavirus disease (COVID-19) has proved to be mostly fatal in older patients further indicates the role that gut microbiota may play in this disease. It is, therefore, plausible that the gut microbiota could be a new therapeutic target and that probiotics could also have a role in the management of the patients affected by COVID-19.
Angiotensin-converting enzyme 2 receptor , Gastrointestinal tract , Gut microbiome , Probiotic , Severe acute respiratory syndrome coronavirus 2 , Virus-host interaction
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Centre for Life Science, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
Department of Microbiology and Virology Named After Sh.I. Sarbasova, Astana Medical University, Nur-Sultan, Kazakhstan
Department of Food Safety and Biotechnology, Armenian National Agrarian University, Yerevan, Armenia
International Association for Human and Animals Health Improvement, Yerevan, Armenia
Chair of Field Therapy, Yerevan State Medical University, Yerevan, Armenia
Department of Virology, Molecular Biology and Genome Research Communicable Diseases, National Centre for Disease Control and Public Health, Tbilisi, Georgia
Lugar Center for Public Health Research, Tbilisi, Georgia
Communicable Diseases, National Centre for Disease Control and Public Health, Tbilisi, Georgia
Kazakhstan Association of Human Microbiome Researchers, Nur-Sultan, Kazakhstan
ReGenera R&D International for Aging Intervention, Milan, Italy
School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
Centre for Life Science
Department of Microbiology and Virology Named After Sh.I. Sarbasova
Department of Food Safety and Biotechnology
International Association for Human and Animals Health Improvement
Chair of Field Therapy
Department of Virology
Lugar Center for Public Health Research
Communicable Diseases
Kazakhstan Association of Human Microbiome Researchers
ReGenera R&D International for Aging Intervention
School of Medicine
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