Strategies for genetic modification of microalgae to improve the production efficiency of liquid biofuel
Kossalbayev B.D. Kakimova A.B. Sadvakasova A.K. Bauenova M.O. Balouch H. Lyaguta M.A. Ahmad F. Kirbayeva D.K. Ozgul S. Allakhverdiev S.I.
27 January 2025Elsevier Ltd
International Journal of Hydrogen Energy
2025#1001301 - 1314 pp.
The application of genetic engineering in biofuel production has advanced significantly, driven by developments in genetic tools and omics technologies. These advancements have enhanced our understanding of lipid and carbohydrate metabolism, opening new avenues for metabolic engineering to optimize biofuel production. This review explores genetic strategies to improve the lipid content and fatty acid profiles for biodiesel production, as well as innovations in engineering for one-step biobutanol synthesis using cyanobacteria. Strategies for carbohydrate accumulation are also examined, highlighting their role in biofuel production. Additionally, the review evaluates the environmental risks associated with large-scale fourth-generation biofuel production. The findings emphasize the potential of genetic engineering to transform microalgae into highly efficient biofuel platforms capable of producing biodiesel, biobutanol, and other liquid biofuels. By addressing critical challenges and leveraging cutting-edge technologies, this research contributes to the development of sustainable and economically viable biofuel production systems.
Biobutanol , Biodiesel , Carbohydrate accumulation , Genetic engineering , Lipid metabolism , Liquid biofuel , Metabolic engineering , Microalgae
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Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Al-Farabi 71, Almaty, 050038, Kazakhstan
Department of Chemical and Biochemical Engineering, Institute of Geology and Oil-Gas Business Institute Named After K. Turyssov, Satbayev University, Satpaev 22, Almaty, 050043, Kazakhstan
Ecology Research Institute, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, 161200, Kazakhstan
Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences (SLS), Northwestern Polytechnical University (NPU), 127 West Youi Road, Beilin District, Xian, 710072, China
Faculty of Engineering and Natural Sciences, Bahçeşehir University, Istanbul, Turkey
Controlled Photobiosynthesis Laboratory, K.A. Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya Street 35, Moscow, 127276, Russian Federation
Faculty of Biology and Biotechnology
Department of Chemical and Biochemical Engineering
Ecology Research Institute
Key Laboratory for Space Biosciences and Biotechnology
Faculty of Engineering and Natural Sciences
Controlled Photobiosynthesis Laboratory
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