Restoration of Disturbed Gut Microbiota in Mice Infected with Multidrug-Resistant Staphylococcus aureus and Treated with Cefazolin is Facilitated by the Application of an Iodine-glycine Complex

Korotetskiy I. Zubenko N. Shilov S. Kuznetsova T. Ivanova L. Krasnoshtanov A. Reva O. Turganbay S.
January-February 2026 Unique Scientific Publishers

International Journal of Veterinary Science
2026 #15 Issue 1 48 - 55 pp.

Antibiotic therapy frequently disrupts the gut microbiota, compromising treatment outcomes and increasing adverse effects. Restoration of the intestinal microbiota is crucial, especially in cases of multidrug-resistant infections. This study evaluated the efficacy of an iodine-glycine complex (CC-195) in restoring the gut microbiota of mice infected with multidrug-resistant Staphylococcus aureus and treated with cefazolin. Mice were categorized into five groups, including controls, monotherapies, and combination therapy. Microbiota composition was analyzed using metagenomic sequencing on the Ion Torrent PGM platform. Taxonomic classification was performed using Kaiju software, and diversity analyses were conducted with R-based bioinformatics packages, including phyloseq and vegan. S. aureus infection and cefazolin monotherapy reduced microbial diversity and promoted dysbiosis, while CC-195, especially in combination with cefazolin, restored beneficial taxa and reduced opportunistic pathogens. These findings underline the potential of iodine-based adjunctive therapies for managing antibiotic-induced microbiome disturbances and combating antibiotic resistance.

Antibiotic Resistance , Dysbacteriosis , Gut Microbiota , Iodine Complex , Metagenomics

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JSC Scientific Center for Anti-Infectious Drugs, Almaty, 050060, Kazakhstan
LLC International Engineering and Technological University, Almaty, 050060, Kazakhstan
LLP Research and Production Association Kazpharmacom, Almaty, 040900, Kazakhstan
Department of Biochemistry, Genetics and Microbiology, Centre for Bioinformatics and Computational Biology, University of Pretoria, Pretoria, 0028, South Africa

JSC Scientific Center for Anti-Infectious Drugs
LLC International Engineering and Technological University
LLP Research and Production Association Kazpharmacom
Department of Biochemistry

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