Simultaneous Immobilization of Gadolinium Ions and Di(o-carborano-1,2-dimethyl)borate on Fe3O4 Nanoparticles
Fe3O4 нанобөлшектеріне ди(о-карборан-1,2-диметил)борат және гадолиний иондарды қатар иммобилизациялау
Одновременная иммобилизация ионов гадолиния и ди(о-карборано-1,2-диметил)бората на наночастицы Fe3O4
Korolkov I.V. Zibert A.V. Lisovskaya L.I. Ludzik K. Anisovich M.V. Vasilyeva M.M. Shumskaya A.E. Usseinov A. Yeszhanov A.B. Zdorovets M.V.
2022E.A.Buketov Karaganda State University Publish House
Bulletin of the Karaganda University Chemistry Series
2022#106Issue 287 - 94 pp.
Neutron capture therapy is a promising method for cancer treatment based on the targeted delivery of specific isotopes into cancer cells and subsequent irradiation with epithermal neutrons. As a result, a large amount of energy is released at a distance comparable to the size of the cell, destroying it from the inside. Magnetic iron oxide nanoparticles can be used for the targeted delivery of isotopes. In this article, iron oxide nanoparticles (Fe3O4) were modified with silanes and polyelectrolyte complexes for simultaneous immobilization of gadolinium ions and carborane compounds through ionic interaction for potential application in targeted delivery into cancer cells for neutron capture therapy. Structure, size and element composition was elucidated by the Fourier-transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDA), dynamic light scattering (DLS) and X-ray diffraction (XRD) analysis. It was found that, according to EDA, resulting nanoparticles consist of 15.4 % boron and 1.5 % gadolinium, with average hydrodynamical size of 386 nm measured by DLS. An in vitro cytotoxicity test using HepG2 (a cancer cell line) and human skin fibroblasts (a normal cell line) showed minor cytotoxicity in concentration range from 0.05 to 1 mg/mL.
BNCT , carborane , cytotoxicity , Fe3O4 nanoparticles , silane , surface modification , targeted delivery of payload
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Institute of Nuclear Physic of the Republic of Kazakhstan, Almaty, Kazakhstan
L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan
University of Lodz, Poland
Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russian Federation
Republican Unitary Enterprise, Scientific-Practical Centre of Hygiene, Minsk, Belarus
Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, Minsk, Belarus
Institute of Nuclear Physic of the Republic of Kazakhstan
L.N. Gumilyov Eurasian National University
University of Lodz
Frank Laboratory of Neutron Physics
Republican Unitary Enterprise
Institute of Chemistry of New Materials
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