Poly(2-vinylpyridine) magnetite nanoparticles for 5-fluorouracil targeted delivery: synthesis, uptake and release study
Korolkov I.V. Izbasar K.A. Bekbol Z.A. Zibert A.V. Shumskaya A.E. Lissovskaya L.I. Korganbayeva L.N. Zdorovets M.V.
November 2024Springer Science and Business Media Deutschland GmbH
Chemical Papers
2024#78Issue 168599 - 8607 pp.
One of the major limitations of anti-cancer drugs is their poor selectivity and high toxicity. The present study aims to overcome these difficulties by developing targeted drug delivery systems. Drug delivery systems were synthesized based on magnetite nanoparticles with grafted poly(2-vinylpyridine) from their pre-modified surface with 3-(trimethoxysilyl)propyl methacrylate. The physical and chemical properties of synthesized samples were examined by Fourier-transform infrared spectroscopy, X-ray diffraction, vibrating-sample magnetometry, Energy-dispersive X-Ray analysis and thermogravimetric analysis. The size of nanoparticles was estimated by DLS, final Fe3O4-TMSPM-P2VP-5FU nanoparticles have an average size of 120 nm (PDI is 0.286). Release of 5-FU was examined at different pH (4.5 and 7.58) and constant temperature of 36.6 °C using UV–Vis spectroscopy.
5-FU , Drug delivery , Iron oxide , Nanoparticle
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The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty, 050032, Kazakhstan
L.N.Gumilyov Eurasian National University, Satpaev Str. 5, Astana, 010008, Kazakhstan
The Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, Minsk, Belarus
The Institute of Nuclear Physics
L.N.Gumilyov Eurasian National University
The Institute of Chemistry of New Materials
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