Modification of magnetic Fe3O4 nanoparticles for targeted delivery of payloads
Модификация магнитных наночастиц Fe3O4 для адресной доставки полезного груза
Пайдалы жүктемені жеткізу үшін магнитті Fe3O4 нанобөлшектерін модификациялау
Korolkov I.V. Ludzik K. Lisovskaya L.I. Zibert A.V. Yeszhanov A.B. Zdorovets M.V.
2021E.A.Buketov Karaganda State University Publish House
Bulletin of the Karaganda University Chemistry Series
2021#17Issue 199 - 108 pp.
The development of methods for targeted delivery of payload is a rapidly developing area of research. For this reason, iron oxide nanoparticles have potential to be used in delivery of substances by using external magnetic field. However it is necessary to develop methods of their modification, which will lead to the possibility of immobilization of payloads with the required concentration for therapeutic use. In this article, supermagnetic iron oxide nanoparticles (Fe3O4) were modified with silanes such as (3-chloropropyl)-trimethoxysilane, (3-mercaptopropyl)trimethoxysilane, (3-aminopropyl)trimethoxysilane and (3-glycidyl-propyl)trimethoxysilane by reaction of polycondensation. Then carborane compound (payload) was successfully attached on the modified nanoparticles via covalent bonding. Structure, size and element composition were studied by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Energy-dispersive X-ray spectroscopy (EDA). It was found that resulting nanoparticles contain 16.6 % of boron (according to EDA), and their average size is 32±9 nm (according to SEM). In vitro test using HeLa (cervical cancer cell) and PC-3 (prostate cancer cell) shows low cytotoxicity in concentration range of 1–200 µg/ml.
Biological test , BNCT , Carborane , Cytotoxicity , Fe3O4 nanoparticles , Silane , Surface modification , Targeted delivery of payload
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Institute of Nuclear Physic of the Republic of Kazakhstan, Almaty, Kazakhstan
L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan
Department of Physical Chemistry, University of Lodz, Poland
Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russian Federation
Institute of Nuclear Physics, Abylay khana 2/1, Nur-Sultan, 010000, Kazakhstan
Institute of Nuclear Physics, Abylay khana 2/1, Nur-Sultan, 010000, Kazakhstan
University of Lodz, ul. Uniwersytecka 3, Łódź, 90–137, Poland
Institute of Nuclear Physics, Abylay khana 2/1, Nur-Sultan, 010000, Kazakhstan
L.N. Gumilyov Eurasian National University, Satbayev str., 2, Nur-Sultan, 010000, Kazakhstan
Institute of Nuclear Physics, Abylay khana 2/1, Nur-Sultan, 010000, Kazakhstan
Institute of Nuclear Physic of the Republic of Kazakhstan
L.N. Gumilyov Eurasian National University
Department of Physical Chemistry
Frank Laboratory of Neutron Physics
Institute of Nuclear Physics
Institute of Nuclear Physics
University of Lodz
Institute of Nuclear Physics
L.N. Gumilyov Eurasian National University
Institute of Nuclear Physics
10 лет помогаем публиковать статьи Международный издатель
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