Boron and gadolinium loaded fe3o4 nanocarriers for potential application in neutron cancer therapy
Korolkov I.V. Zibert A.V. Lissovskaya L.I. Ludzik K. Anisovich M. Kozlovskiy A.L. Shumskaya A.E. Vasilyeva M. Shlimas D.I. Jażdżewska M. Marciniak B. Kontek R. Chudoba D. Zdorovets M.V.
2 August 2021MDPI
International Journal of Molecular Sciences
2021#22Issue 16
In this article, a novel method of simultaneous carborane-and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 nanoparticles were treated with silane and then the polyelectrolytic layer was formed for fur-ther immobilization of NCT agents. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), ultraviolet–visible (UV-Vis) and Mössbauer spectroscopies, dynamic light scattering (DLS), scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) were applied for the characterization of the chemical and element composition, structure, mor-phology and magnetic properties of nanocarriers. The cytotoxicity effect was evaluated on different cell lines: BxPC-3, PC-3 MCF-7, HepG2 and L929, human skin fibroblasts as normal cells. average size of nanoparticles is 110 nm; magnetization at 1T and coercivity is 43.1 emu/g and 8.1, respectively; the amount of B is 0.077 mg/g and the amount of Gd is 0.632 mg/g. Successful immobilization of NCT agents, their low cytotoxicity against normal cells and selective cytotoxicity against cancer cells as well as the superparamagnetic properties of nanocarriers were confirmed by analyses above.
Carborane , Cytotoxicity , Gadolinium , NCT , Superparamagnetic Fe3O4 nanoparticles , Targeted drug delivery
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The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty, 050032, Kazakhstan
Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan, 010008, Kazakhstan
Department of Physical Chemistry, University of Lodz, Lodz, 90-236, Poland
Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation
Republican Unitary Enterprise, Scientific-Practical Centre of Hygiene, Minsk, 220012, Belarus
The Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, Minsk, 220072, Belarus
Faculty of Physics, Adam Mickiewicz University, Poznan, 61-614, Poland
Laboratory of Cytogenetics, Faculty of Biology and Enviromental Protection, University of Lodz, Lodz, 90-231, Poland
Department of Intelligent Information Technologies, Ural Federal University, Mira Str. 19, Ekaterinburg, 620002, Russian Federation
The Institute of Nuclear Physics
Engineering Profile Laboratory
Department of Physical Chemistry
Frank Laboratory of Neutron Physics
Republican Unitary Enterprise
The Institute of Chemistry of New Materials
Faculty of Physics
Laboratory of Cytogenetics
Department of Intelligent Information Technologies
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