Microenvironment of Solid Tumors
Korneenko T.V. Pestov N.B. Shakhparonov M.I. Barlev N.A.
23 September 2025
Frontiers in bioscience (Landmark edition)
2025#30Issue 936940 pp.
The tumor microenvironment (TME) plays a fundamental role in tumor progression. Cancer cells interact with their surroundings to establish a supportive niche through structural changes and paracrine signaling. Cells around transformed tumor cells contribute to cancer development, while infiltrating immune cells in this aggressive TME often become exhausted. Solid tumors, especially the most invasive types such as pancreatic ductal adenocarcinoma, are notably stiff mechanically, with cross-linking enzymes significantly affecting the survival of cancer cells in both primary tumors and metastatic sites. In this review, we highlight recent key contributions to the field, focusing on single-cell sequencing of stromal cells, which are increasingly seen as highly heterogeneous yet classifiable into distinct subtypes. These new insights enable the development of effective co-treatment approaches that could significantly enhance current and novel therapies against the most aggressive cancers.
cancer , cancer-associated cells , desmoplasia , extracellular matrix , metastasis
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Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997, Moscow, Russian Federation
Laboratory of Tick-Borne Encephalitis and Other Viral Encephalitides, Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, 108819 Moscow, Russian Federation
Vavilov Institute of General Genetics, 119991, Moscow, Russian Federation
Department of Biomedicine to Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, 02000, Kazakhstan
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Laboratory of Tick-Borne Encephalitis and Other Viral Encephalitides
Vavilov Institute of General Genetics
Department of Biomedicine to Department of Biomedical Sciences
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