Development of a Fuzzy Diagnostic Model of Ischemic Disease of the Lower Limbs for Different Stages of Patient Management

Korenevskiy N.A. Bykov A.V. Al-Kasasbeh R.T. Al-Smady M.M. Aikeyeva A.A. Al-Jund M. Al-Kasasbeh E.T. Rodionova S.N. Ilyash M. Shaqadan A.
2022 Begell House Inc.

Critical Reviews in Biomedical Engineering
2022 #50 Issue 4 13 - 30 pp.

Ischemic disease has severe impact on patients which makes accurate diagnosis vital for health protection. Improving the quality of prediction of patients with ischemic extremity disease by using hybrid fuzzy model allows for early and accurate prognosis of the development of the disease at various stages. The prediction of critical ischemia of lower extremity (CLI) at various disease stages is complex problem due to inter-related factors. We developed hybrid fuzzy decision rules to classify ischemic severity using clinical thinking (natural intelligence) with artificial intelligence, which allows achieving a new quality in solving complex systemic problems and is innovative. In this study mathemat-ical model was developed to classify the risk level of CLI into: subcritical ischemia, favorable outcome, questionable outcome, and unfavorable outcome. The prognosis is made using such complex indicators as confidence that the patient will develop gangrene of the lower extremity (unfavorable outcome), complex coefficient of variability, and reversibility of the ischemic process. Model accuracy was calculated using representative control samples that showed high diagnostic accuracy and specificity characterizing the quality of prediction are 0.9 and higher, which makes it possible to recom-mend their use in medical practice.

critical ischemia , diagnostic , fuzzy logic , gangrene of the lower extremities , ischemic disease , membership functions , risk of occurrence

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South-West State University, Kursk, Russian Federation
Kursk Regional Clinical Hospital, Kursk, Russian Federation
Department of Mechatronics Engineering, School of Engineering, University of Jordan, Amman, Jordan
Jordan University, Amman, Jordan
Eurasian National University named after L.N. Gumilyov, Nur-Sultan, Kazakhstan
Department of Endocrinology, Eunice Kennedy Shriver National Institute of Child and Human Development, National Institutes of Health, Bethesda, MD, United States
Al-Karak College, Al-Balqa Applied University, Amman, Jordan
Zarqa University, Civil Engineering Department, Jordan
ITMO University, Kronverksky Pr. 49, Bldg. A, St. Petersburg, 197101, Russian Federation

South-West State University
Kursk Regional Clinical Hospital
Department of Mechatronics Engineering
Jordan University
Eurasian National University named after L.N. Gumilyov
Department of Endocrinology
Al-Karak College
Zarqa University
ITMO University

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