Vibroacoustic therapy in the treatment of patients with COVID-19 complicated by respiratory failure: a pilot randomized controlled trial
Konkayev A. Bekniyazova A.
2023Frontiers Media SA
Frontiers in Medicine
2023#10
Introduction: Coronavirus infection is a dangerous airborne disease that can lead to serious lung damage. Data on the effectiveness of low-frequency chest vibrations in the treatment of lung diseases are available; however, not so many of them exist. Vibroacoustic pulmonary therapy is a component of physiotherapy that improves lung perfusion and drainage without requiring active patient participation. This study aimed to increase statistical efficiency through maximizing the relevant information obtained from the clinical data. Calculating the sample size to determine the power of subsequent studies was also necessary. Research methods: A pilot randomized parallel trial involving 60 patients was conducted. The patients were divided into two equal groups, where they received sessions of vibroacoustic pulmonary therapy using the “VibroLung” device in two modes “acute respiratory distress syndrome (ARDS)” and “Pneumonia,” with identical treatment. The patients were > 18 years old with detected COVID-19 by PCR and grade 2 and 3 lung lesions detected by computer tomography (CT). Blood sampling was performed in the morning at the same time before and after the hardware massage to determine PaO2, PaCO2, and P/F. Results: As a result of the test, the following data were obtained: on the first day in the group using the “ARDS” mode, PaO2 indicators averaged 65, CI 95% [58.6–73.2] and on average 77.5, CI 95% [69.8–85.2], “before” and “after,” respectively, which indicates improved oxygenation after the procedure. However, in the second group with the “Pneumonia” mode after its use, PaCO2 was higher after the session, on average 48.7, CI 95% [40.8–56.6], whereas before that, the following indicators had, on average 43.6, CI 95% [37.2–50]. Conclusion: Thus, the data obtained yielded ambiguous results, which are the basis for further study in future randomized controlled trials. As the treatment of coronavirus infection has no etiological treatment, even small shifts in the therapy of this category of patients can be significant. Clinical trial registration: ClinicalTrials.gov, identifier NCT05143372. Copyright
COVID-19 , physiotherapy , pilot randomized trial , respiratory insufficiency , vibroacoustic therapy
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Department of Anesthesiology and Intensive Care, Astana Medical University, Astana, Kazakhstan
The National Scientific Center of Traumatology and Orthopedics Named After Academician Batpenov N.D, Astana, Kazakhstan
Department of Anesthesiology and Intensive Care
The National Scientific Center of Traumatology and Orthopedics Named After Academician Batpenov N.D
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