Association of four genetic variants with colorectal cancer in kazakhstan population

Kolesnikova Y. Babenko D. Kadyrova I. Kolesnichenko S. Akhmaltdinova L. Korshukov I. Kabildina N. Sirota V. Zhumaliyeva V. Taizhanova D. Vazenmiller D. Turmukhambetova A.
12 October 2021 Impact Journals LLC

Oncotarget
2021 #12 Issue 21 2215 - 2222 pp.

The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudio 12K Flex PCR. For four significant SNPs inheritance model analysis was performed. Increasing risk of CRC was noted for rs10795668 in log-additive model (OR = 1.45, 95% CI: 1.05-1.99, p = 0.023); for rs1035209 in log-additive model (OR = 1.79, 95% CI: 1.18-2.72, p = 0.003); for rs11190164 in log-additive model (OR = 1.67, 95% CI: 1.17-2.38, p = 0.004). Decreasing risk of CRC was noted for rs10506868 in log-additive model (OR = 0.56, 95% CI: 0.37-0.85, p = 0.006). We detected SNPs that are associated with CRC risk in the Kazakhstan population.

Colorectal adenocarcinoma , Rs1035209 , Rs10506868 , Rs10795668 , Rs11190164

Text of the article Перейти на текст статьи

Department of Biomedicine, Karaganda Medical University, Karaganda, 100008, Kazakhstan
Research and Scientific Center, Karaganda Medical University, Karaganda, 100008, Kazakhstan
Shared Resource Laboratory, Karaganda Medical University, Karaganda, 100008, Kazakhstan
Department of Oncology and Radiation Diagnostics, Karaganda Medical University, Karaganda, 100008, Kazakhstan
Department of Internal Medicine, Karaganda Medical University, Karaganda, 100008, Kazakhstan
Department of Obstetrics, Gynecology and Perinatology, Karaganda Medical University, Karaganda, 100008, Kazakhstan
Department of Strategic Development and Science, Karaganda Medical University, Karaganda, 100008, Kazakhstan

Department of Biomedicine
Research and Scientific Center
Shared Resource Laboratory
Department of Oncology and Radiation Diagnostics
Department of Internal Medicine
Department of Obstetrics
Department of Strategic Development and Science

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026