Structural and Spectroscopic Study of Benzoperimidines Derived from 1-Aminoanthraquinone and Their Application to Bioimaging
Kirilova E. Maļeckis A. Kirjušina M. Mežaraupe L. Rubeniņa I. Brakovska A. Pavlova V. Kecko S. Umbraško I. Kiyan V. Lider L. Pučkins A. Belyakov S.
November 2025Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2025#30Issue 22
In this research, we studied the synthesis and characterization of a novel amidine derivative of benzoperimidine derived from 1-aminoanthraquinone, focusing on its emission properties and potential applications in confocal laser scanning microscopy. The synthesized compound exhibited pronounced solvatochromic behavior in various solvents. Spectroscopic analysis, including 1H-, 13C-, and mass spectrometry, confirmed the chemical structure. The structure of three compounds was also determined using X-ray diffraction analysis; this study revealed the structural features of these substances in the solid state. The compound’s antimicrobial activity was evaluated using the agar diffusion method with the bacterium Bacillus subtilis subsp. Spizizenii. Furthermore, the study introduces a dye designed for imaging of the parasitic flatworm Opisthorchis felineus, demonstrating its potential in visualizing biological specimens.
anthraquinone , benzoperimidine , confocal laser scanning microscopy , crystal structure , fluorescence , toxicology
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Department of Environment and Technologies, Faculty of Natural Sciences and Healthcare, Daugavpils University, Daugavpils, LV-5401, Latvia
Department of Ecology, Institute of Life Sciences and Technology, Daugavpils University, Daugavpils, LV-5401, Latvia
Laboratory of Biodiversity and Genetic Resources, National Center for Biotechnology, 13/5 Kurgalzhynskoye Road, Astana, 010000, Kazakhstan
Faculty of Veterinary Medicine and Animal Husbandry Technology, S. Seifullin Kazakh Agro Technical Research University, 62 Zhenis Avenue, Astana, 010011, Kazakhstan
Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV-1006, Latvia
Department of Environment and Technologies
Department of Ecology
Laboratory of Biodiversity and Genetic Resources
Faculty of Veterinary Medicine and Animal Husbandry Technology
Latvian Institute of Organic Synthesis
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