Genome-guided approaches and evaluation of the strategies to influence bioprocessing assisted morphological engineering of Streptomyces cell factories
Khushboo Thakur M. Kumar P. Rajput D. Yadav V. Dhaka N. Shukla R. Kumar Dubey K.
May 2023Elsevier Ltd
Bioresource Technology
2023#376
Streptomyces genera serve as adaptable cell factories for secondary metabolites with various and distinctive chemical structures that are relevant to the pharmaceutical industry. Streptomyces’ complex life cycle necessitated a variety of tactics to enhance metabolite production. Identification of metabolic pathways, secondary metabolite clusters, and their controls have all been accomplished using genomic methods. Besides this, bioprocess parameters were also optimized for the regulation of morphology. Kinase families were identified as key checkpoints in the metabolic manipulation (DivIVA, Scy, FilP, matAB, and AfsK) and morphology engineering of Streptomyces. This review illustrates the role of different physiological variables during fermentation in the bioeconomy coupled with genome-based molecular characterization of biomolecules responsible for secondary metabolite production at different developmental stages of the Streptomyces life cycle.
Anti-obesity drug , Bioprocess engineering , Microparticle enhanced cultivation , Morphology engineering , Pellet modulation
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Department of Biotechnology, Central University of Haryana, Mahendergarh, 123031, India
Department of Microbiology, Central University of Haryana, Mahendergarh, 123031, India
Department of Morphology and Physiology, Karaganda Medical University, Karaganda, 100008, Kazakhstan
Bioprocess Engineering Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India
Department of Biotechnology, Institute of Applied Sciences and Humanities, GLA University, U.P., Mathura-, 281406, India
Department of Biotechnology
Department of Microbiology
Department of Morphology and Physiology
Bioprocess Engineering Laboratory
Department of Biotechnology
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