Chemical constituents from Ferula songarica Pall. ex Spreng. and its chemotaxonomic significance
Khosnutdinova T. Abd Karim H.A. Norazhar A.I. Ideris S. Osman C.P. Ismail N.H. Sultanova N.
June 2026Elsevier Ltd
Biochemical Systematics and Ecology
2026#126
Ferula L. has diverse phytochemicals, primarily sesquiterpenes, sesquiterpene coumarins, and sesquiterpene chromones, many of which demonstrate a wide range of biological activities. Despite the potential of phytochemicals of the genus, Ferula songarica Pall. ex Spreng. remains poorly investigated. Though widely used in folk medicine, reports on its phytochemical constituents are limited. This study aims to isolate and characterize chemical constituents from the aerial and root parts of F. songarica. Exhaustive chromatographic procedures on the dichloromethane and methanol extracts afforded six compounds, including three flavonoids, two sterols, and one hydroxybenzoic acid derivative, namely quercetin-3-O-β-D-glucopyranoside 1, quercetin-3-O-α-L-arabinopyranoside 2, isorhamnetin-3-O-β-D-galactopyranoside 3, stigmasterol 4, β-sitosterol 5, and 3-farnesyl-4-hydroxybenzoic acid 6. Structural elucidation was achieved through comprehensive spectroscopic analysis and comparison with reported data. The rare presence of flavonoid glycosides in F. songarica highlights the phylogenetic and chemotaxonomic significance of Ferula within the Apioideae subfamily. These findings contribute to the understanding of chemotypic variation within the genus Ferula. Overall, these findings expand current knowledge of chemotypic variation in Ferula and suggest adaptive metabolic responses to ecological stress.
Apiaceae , Apioideae , Ferula , Ferula songarica
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Department of Chemistry, Faculty of Natural Sciences, L. N. Gumilyov Eurasian National University, Astana, 010000, Kazakhstan
Malaysian Institute of Pharmaceuticals and Nutraceuticals, National Institutes of Biotechnology Malaysia, Halaman Bukit Gambir, Gelugor, Pulau Pinang, 11700, Malaysia
Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, Bandar Puncak Alam, Selangor, 42300, Malaysia
Faculty of Applied Sciences, Universiti Teknologi MARA, Selangor, Shah Alam, 40450, Malaysia
Department of Chemistry
Malaysian Institute of Pharmaceuticals and Nutraceuticals
Atta-ur-Rahman Institute for Natural Product Discovery
Faculty of Applied Sciences
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