Advanced Pain Management in Patients with Terminal Cancer
Khojayeva K. Aubakirova M. Viderman D.
2025Bentham Science Publishers
Current Medicinal Chemistry
2025
Understanding and managing pain in patients with terminal cancer is a vital aspect of palliative care, aimed at relieving suffering and improving quality of life in the final stages of illness. Studies indicate that approximately 50% of patients with stage 4 cancer report moderate to severe pain, with a quarter experiencing severe cancer-related pain. Despite opioid prescriptions in 97% of cases, a significant portion of patients continues to suffer unresolved pain during the last week of life. Cancer-related pain is multifaceted, often involving nociceptive, neuropathic, and mixed elements, necessitating a thorough, multidimensional approach to both assessment and treatment. The challenge of opioid tolerance and the potential for addiction demands careful monitoring. Interventional therapies, including nerve blocks and spinal cord stimulation, are gaining attention as valuable complements or alternatives to opioid use. Additionally, alternative methods like yoga, special diets, and food supplements provide diverse options for managing pain. Psychological therapies, including cognitive-behavioral techniques and mindfulness, address the mental and emotional dimensions of pain. Emerging technologies, including artificial intelligence, hold promise for optimizing pain management in terminal cancer care. This review explores advanced pain management strategies, focusing on traditional opioid therapies, modern pharmaceutical innovations, and non-pharmacological approaches such as alternative medicine, massage, dietary interventions, and psychological therapy.
cancer-related pain , interventional therapy , non-pharmacological interventions , opioids , Pain management , terminal cancer
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Department of Surgery, School of Medicine, Nazarbayev University, 5/1 Kerey and Zhanibek khandar str., Astana, 020000, Kazakhstan
Department of Anesthesiology, Intensive Care and Pain Medicine, National Research Oncology Center, 3 Kerey and Zhanibek Khandar, Astana, 020000, Kazakhstan
Department of Surgery
Department of Anesthesiology
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026