Investigation of a Natural Antibiotics Properties Effective against Resistant Opportunistic Pathogenic Infections

Khassenova A. Shorabayev Y. Zhantlessova S. Baimakhanova B. Sultanova A. Yelubaeva M.
2025 Korean Society for Microbiolog and Biotechnology

Journal of Microbiology and Biotechnology
2025 #35

The widespread use of antibiotics has led to several negative consequences, including the development of multidrug resistance in microorganisms to previously effective medications. Antibiotic resistance is an increasingly critical issue in both inpatient and outpatient settings. The problem is complicated by the decline in the development of innovative drugs to combat the most dangerous and resistant pathogens. One approach to addressing this challenge is to search for producers of new natural compounds with antibiotic activity. The primary objective of this study was to identify streptomycetes capable of synthesizing complex antibiotics with antibacterial properties. In this study, actinomycetes were isolated from the arid soils in Kazakhstan, followed by the analysis of their antagonistic properties. The greatest interest was generated by isolate No. 312, obtained from rocky soils of the Almaty region and grown on oat agar. The article describes the biochemical, cultural-taxonomic, and antagonistic properties of the new actinomycete. The new antibiotic exhibited the strongest antagonistic activity against clinical strains of Staphylococcus aureus (MRSA) and Escherichia coli (ESBL) with various types of resistance. The inhibition zone diameter for S. aureus was 32 ± 0.2 mm, and for E. coli—20 ± 0.1 mm. This field is actively advancing in leading countries worldwide and holds particular importance for Kazakhstan, where the biotechnological industry lacks domestic producers of antibiotics currently used in medical practice, as well as producers of new competitive pharmaceuticals. Copyright

Actinomycetes , antibacterial properties , antibiotics , opportunistic pathogenic bacteria , spectrum of activity

Text of the article Перейти на текст статьи

Industrial Microbiology LLP, Almaty, 050040, Kazakhstan
Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Research and Production Center for Microbiology and Virology LLP, Almaty, 050010, Kazakhstan

Industrial Microbiology LLP
Al-Farabi Kazakh National University
Research and Production Center for Microbiology and Virology LLP

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026