Guillain-Barre syndrome: An autoimmune disorder post-COVID-19 vaccination?
Khan Z. Ahmad U. Ualiyeva D. Amissah O.B. Khan A. Noor Z. Zaman N.
December 2022Elsevier Inc.
Clinical Immunology Communications
2022#21 - 5 pp.
SARS-CoV-2 causes Coronavirus Disease 2019 (COVID-19), an infectious condition that can present none or one or more of these symptoms: fever, cough, headache, sore throat, loss of taste and smell, aches, fatigue and musculoskeletal pain. For the prevention of COVID-19, there are vaccines available including those developed by Pfizer, Moderna, Sinovac, Janssen, and AstraZeneca. Recent evidence has shown that some COVID-19-vaccinated individuals can occasionally develop as a potential side effect Guillain-Barre syndrome (GBS), a severe neurological autoimmune condition in which the immune response against the peripheral nerve system (PNS) can result in significant morbidity. GBS had been linked previously to several viral or bacterial infections, and the finding of GBS after vaccination with certain COVID-19, while rare, should alert medical practitioners for an early diagnosis and targeted treatment. Here we review five cases of GBS that developed in different countries after COVID-19 vaccination.
AstraZeneca , Autoimmune , COVID-19 , Guillain-Barre syndrome , Moderna , Pfizer , Vaccine
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State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China
University of Chinese Academy of Sciences, Beijing, 100049, China
Center for Biotechnology and Microbiology, University of Swat, Pakistan
Department of Herpetology, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Ministry of Education, Key Laboratory of Cell Activities and Stress Adaptations, School of life sciences, Lanzhou University, Gansu, 730000, China
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong, China
Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
State Key Laboratory of Respiratory Disease
University of Chinese Academy of Sciences
Center for Biotechnology and Microbiology
Department of Herpetology
Faculty of Biology and Biotechnology
Ministry of Education
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology
Key Laboratory of Applied Marine Biology
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