Thiadiazole and Thiazole Derivatives as Potential Antimicrobial Agents
Khamitova А. Berillo D. Lozynskyi A. Konechnyi Y. Mural D. Georgiyants V. Lesyk R.
2024Bentham Science Publishers
Mini-Reviews in Medicinal Chemistry
2024#24Issue 5531 - 545 pp.
Background: This review summarizes data on heterocyclic systems with thiadiazole and thiazole fragments in molecules as promising antimicrobial agents. Introduction: Thiadiazole and thiazole backbones are the most favored and well-known heterocy-cles, a common and essential feature of various drugs. These scaffolds occupy a central position and are the main structural components of numerous drugs with a wide spectrum of action. These in-clude antimicrobial, antituberculous, anti-inflammatory, analgesic, antiepileptic, antiviral, and anti-cancer agents. Method: The research is based on bibliosemantic and analytical methods using bibliographic and abstract databases, as well as databases of chemical compounds. Result: This review reports on thiadiazole and thiazole derivatives, which have important pharmacological properties. We are reviewing the structural modifications of various thiadiazole and thia-zole derivatives, more specifically, the antimicrobial activity reported over the last years, as we have taken this as our main research area. 80 compounds were illustrated, and various derivatives containing hydrazone bridged thiazole and pyrrole rings, 2-pyridine and 4-pyridine substituted thiazole derivatives, compounds containing di-, tri-and tetrathiazole moieties, spiro-substituted 4-thiazolidinone-imidazoline-pyridines were analyzed. Derivatives of 5-heteroarylidene-2,4-thiazolidinediones, fluoroquinolone-thiadiazole hybrids, and others. Conclusion: 1,3,4-thiadiazoles and thiazoles are valuable resource for researchers engaged in rational drug design and development in this area.
antimicrobial activity , antituberculous activity , drug research , heterocycles , thiadiazole derivatives , thiazole derivatives
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Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, NJSC «Asfendiyarov Kazakh National Medical University», 94 Tole Bi, Almaty, 050000, Kazakhstan
Department of Chemistry and Biochemical Engineering, Institute of Chemical and Biological Technologies (IHBT), Satbayev University, 22 Satbaev, Almaty, 050013, Kazakhstan
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine
Department of Microbiology, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine
Department of Pharmaceutical Chemistry, National University of Pharmacy, 4 Valentynivska, Kharkiv, 61168, Ukraine
Department of Biotechnology and Cell Biology, University of Information Technology and Management in Rzeszow, 2 Sucharskiego, Rzeszow, 35-225, Poland
Department of Pharmaceutical and Toxicological Chemistry
Department of Chemistry and Biochemical Engineering
Department of Pharmaceutical
Department of Microbiology
Department of Pharmaceutical Chemistry
Department of Biotechnology and Cell Biology
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