Antiphospholipid antibodies in the pathogenesis of obstetric pathology: A review of the literature
Khalmirzaeva M.M. Mamedalieva N.M. Kurmanova A.M. Anartayeva G.Zh. Kypshakbaeva Z.N.
31 December 2024Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2024#2024Issue 428 - 35 pp.
Relevance: Antiphospholipid syndrome (AFS) is associated with an increased risk of thrombotic complications and, as a result, the risk of pregnancy complications. Recent studies on the role of non-critical antiphospholipid antibodies in the development of obstetric pathology have shown new aspects of the pathogenesis of these conditions, which opens up potential opportunities for the development of early diagnosis and personalized therapeutic approaches. The study aimed to identify antiphospholipid antibodies role in the pathogenesis of obstetric pathology (miscarriage, recurrent implantation disorders, early preeclampsia). Materials and Methods: The publications for analysis were searched in the Google Scholar, Willey, and PubMed databases from 2015 to 2023 using the keywords “antiphospholipid syndrome,” “antiphospholipid antibodies,” “non-critical antibodies,” “miscarriage,” “recurrent implantation disorders,” and “preeclampsia.” Results: The association between AFS and obstetric pathology in the form of implantation disorders during spontaneous pregnancy and induced after in vitro fertilization and embryo transfer, preeclampsia is based on common pathophysiological mechanisms associated with impaired vascular function and increased tendency to thrombosis. Conclusion: Timely diagnosis and monitoring of laboratory parameters of the hemostasis system open up prospects for the development of potential biomarkers for predicting habitual miscarriage and recurrent implantation disorders in AFS and hypertensive conditions during pregnancy, which has potential significance for improving the quality of life of patients.
antiphospholipid antibodies , antiphospholipid syndrome , implantation disorders , miscarriage , non-critical antibodies , preeclampsia
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Al-Farabi Kazakh National University, Almaty, Kazakhstan
Kazakhstan Medical University “Kazakhstan’s School of Public Health,”, Almaty, Kazakhstan
Scientific Center for Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan
Al-Farabi Kazakh National University
Kazakhstan Medical University “Kazakhstan’s School of Public Health
Scientific Center for Obstetrics
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