Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study
Kenzhina L.B. Mamyrbayeva A.N. Lukashenko S.N. Baigazinov Z.A. Biyakhmetova D.B. Panitskiy A.V. Polivkina E. Zhamaldinov F.F. Patrono C. Palma V. Testa A.
July 2022MDPI
International Journal of Environmental Research and Public Health
2022#19Issue 14
Kazakhstan is known as a country with a complex radioecological situation resulting from different sources such as a natural radiation background, extensive activities of the industrial system of the former Soviet Union and a well-known testing of nuclear power weapons occurred in the Semipalatinsk Test Site (STS) area. The present study focuses on the assessment of the background of dicentric chromosomes in Kazakhstan’s population, which is the starting point in the dose assessment of irradiated people, since the baseline level of spontaneous dicentrics can vary significantly in different populations. In this context, aiming to determine the background frequency of chromosome aberrations in the population of Kazakhstan, considering the heterogeneity of natural radiation background levels of its large territory, a selection of 40 control subjects living in four cities of North, South, West and East Kazakhstan was performed. The cytogenetic study on the selected groups showed fairly low background frequency values of chromosome aberrations (0.84 ± 0.83 per 1000 cells), comparable with other data in the literature on general populations, reporting background frequency values between 0.54 and 2.99 per 1000 cells. The obtained results should be taken into account when constructing the dose–effect calibration curve used in cytogenetic biodosimetry, as a “zero” dose point, which will reduce the uncertainty in quantifying the individual absorbed dose in emergency radiological situations.
background frequency , dicentrics , Kazakhstan population , radiation-induced chromosome aberrations
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Institute of Radiation Safety and Ecology NNC RK, Beibit Atom 2, Building 23, Kurchatov, 071100, Kazakhstan
Institute of Radiology and Agroecology, Kievskoe Shosse 109 km, Kaluga Region, Obninsk, 249032, Russian Federation
National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Center, Via Anguillarese, 301, Rome, 00123, Italy
Institute of Radiation Safety and Ecology NNC RK
Institute of Radiology and Agroecology
National Agency for New Technologies
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