The effect of immunomodulatory therapy with recombinant human interferon alpha-2β on blood cytokine levels in children with recurrent episodes of acute obstructive bronchitis
Kenzhetaeva T. Lukyanenko N.S. Kaliakpar D.M. Dolinnaya V.T. Tkachenko O.
September 2023Oxford University Press
Clinical and Experimental Immunology
2023#213Issue 3310 - 316 pp.
The high incidence of children with recurrent episodes of acute obstructive bronchitis is a widespread problem. Correct identification of children at risk of developing bronchial asthma at school age may improve treatment and prevention approaches to this pathology, but the ability to identify these children remains limited. The purpose of the study was to determine the effectiveness of recombinant interferon alpha-2β in children with recurrent episodes of acute obstructive bronchitis in the course of treatment based on the assessment of cytokine profile. The study examined 59 children of the main group with recurrent episodes of acute obstructive bronchitis and 30 children of the comparison group who suffered from acute bronchitis, aged 2-8 years, who were in the hospital. The results of laboratory studies were compared with the data of 30 healthy children. In children with recurrent episodes of acute obstructive bronchitis, the content of serum interferon-γand interleukin-4 was significantly reduced compared to healthy children, after treatment with recombinant human interferon alpha-2β, the content of interferon-γand interleukin-4 in children significantly increased. The content of interleukin-1β in children with recurrent episodes of acute obstructive bronchitis was significantly higher than in healthy children, after immunomodulatory therapy with recombinant interferon alpha-2β, interleukin-4 normalized to its level in healthy children. It was found that children with recurrent episodes of acute obstructive bronchitis have an imbalance of cytokines, the effectiveness of recombinant human interferon alpha-2β therapy, which normalized the levels of the studied cytokines in the serum.
inflammatory process , interferon-γ , interleukin-1β , interleukin-4 , serum
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Department of Pediatrics and Neonatology, Karaganda Medical University, Karaganda, Kazakhstan
Department of Clinical Genetics, Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine, 31a M. Lysenko Str., Lviv, 79008, Ukraine
Department of Propaedeutics of Pediatrics and Medical Genetics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Department of Pediatrics and Medical Rehabilitation named after Tusupova D.M., Semey Medical University, Semey, Kazakhstan
Department of Propaedeutics of Childhood Diseases, Semey Medical University, Semey, Kazakhstan
Department of Clinical Pharmacology and Clinical Pharmacy, Bogomolets National Medical University, Kyiv, Ukraine
Department of Pediatrics and Neonatology
Department of Clinical Genetics
Department of Propaedeutics of Pediatrics and Medical Genetics
Department of Pediatrics and Medical Rehabilitation named after Tusupova D.M.
Department of Propaedeutics of Childhood Diseases
Department of Clinical Pharmacology and Clinical Pharmacy
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