Hematopoietic stem cell transplantation for multiple myeloma in Kazakhstan: Ten-year single-center experience
Kemaykin V. Burkitbayev Z. Karabekov A. Kolesnikova O. Zhakhina G. Saparbay J. Vildanova R. Idrisova A. Zharlyganova D. Kuanysh Z.
January 2026SAGE Publications Ltd
Journal of International Medical Research
2026#54Issue 1
Objective: This study aimed to evaluate treatment patterns and clinical outcomes among patients with multiple myeloma treated at a major cancer center in Kazakhstan over a 10-year period. Methods: This retrospective observational study analyzed data from 261 patients with multiple myeloma treated at the National Research Oncology Center, Astana, between 2010 and 2021. Sociodemographic and clinical characteristics, treatment regimens, and survival outcomes were assessed using data from electronic medical records. Results: Most patients were diagnosed with stage II of multiple myeloma, based on the Durie–Salmon staging system, and the majority received bortezomib plus dexamethasone as first-line treatment. Hematopoietic stem cell transplantation was performed in 117 (45%) patients, with a 5-year overall survival rate of 63.6%, compared with 46.2% in patients who received chemotherapy alone. Conclusions: The mean age of this cohort was 54 years, suggesting an earlier onset of multiple myeloma in the Kazakh population. Treatment regimens, stem cell yield, and post-transplant complications significantly influenced survival outcomes, underscoring the need to optimize transplant strategies and supportive care in Kazakhstan.
autologous hematopoietic stem cell transplantation , blood cancer , Multiple myeloma , survival analysis
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Center for Oncohematology and Bone Marrow Transplantation, National Research Oncology Center, Kazakhstan
Chairman of the Board, National Research Oncology Center, Kazakhstan
School of Medicine, Nazarbayev University, Kazakhstan
Center for Hepatopancreatobiliary Surgery, Oncohepatology and Organ Transplantation, National Research Oncology Center, Kazakhstan
Department of Science, National Research Oncology Center, Kazakhstan
Center for Oncohematology and Bone Marrow Transplantation
Chairman of the Board
School of Medicine
Center for Hepatopancreatobiliary Surgery
Department of Science
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