Synthesis of hydrolytically and oxidation-responsive networks using thiol-ene “click” chemistry with pentaerythritol tetrakis(3-mercaptopropionate) and tri/tetra-acrylates
Kazybayeva D.S. Irmukhametova G.S. Khutoryanskiy V.V.
July 2021John Wiley and Sons Ltd
Polymers for Advanced Technologies
2021#32Issue 72682 - 2689 pp.
Thiol-ene click reactions of pentaerythritol tetrakis(3-mercaptopropionate) with pentaerythritol tetraacrylate and trimethylolpropane triacrylate were used to prepare polymeric degradable networks. The structure and properties of these networks were studied using Fourier-transform infrared and Raman spectroscopy, thermal gravimetric analysis and scanning electron microscopy. Degradation of these materials was evaluated in different media including phosphate buffer with and without esterase as well as in oxidative environment with hydrogen peroxide. Exposure of the samples to these media results in their degradation. Slow hydrolytic degradation was observed in phosphate buffer and it was not accelerated by the presence of an enzyme. Faster degradation is observed in solutions of hydrogen peroxide. The mechanisms of this degradation are discussed.
biodegradation , hydrolysis , networks , oxidation , thiol-ene click , thiols
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Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Reading School of Pharmacy, University of Reading, Reading, United Kingdom
Department of Chemistry and Chemical Technology
Reading School of Pharmacy
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