Pressure Ulcers and Nutrients: From Established Evidence to Gaps in Knowledge
Kassym L. Zhetmekova Z. Kussainova A. Semenova Y. Vetrova A. Nurzhan S. Sarbassova G. Akhmetova A. Orazalina A. Uzbekova S. Bjørklund G.
2025Bentham Science Publishers
Current Medicinal Chemistry
2025#32Issue 275630 - 5657 pp.
Pressure ulcers (PUs) are caused by continuous pressure or friction on the skin that damages tissue, especially over bony prominences. A critical factor in the development and progression of PUs is poor nutritional status, which often involves deficiencies in essential nutrients such as proteins, vitamins (A, C, D, E, K, and the B complex), and trace elements (including zinc, selenium, copper, iron, and manganese). These micronutrients are vital for effective wound healing, as they play significant roles in cellular repair, immune function, and tissue regeneration. Laboratory tests for serum albumin, prealbumin, transferrin, retinol-binding protein, and anthropometric measures like height, weight, and body mass index (BMI) are used to evaluate a patients nutritional status. Screening tools such as the Mini Nutritional Assessment (MNA), Malnutrition Universal Screening Tool (MUST), LPZ questionnaire, and Subjective Global Assessment (SGA) are commonly employed. Emerging evidence from various studies, including in vitro, in vivo, and clinical trials, underscores the importance of personalized nutritional interventions in managing PUs. Unlike generic dietary plans, tailored nutrition that addresses the specific needs of individuals shows greater potential in promoting wound healing and improving clinical outcomes. This synthesis of existing research highlights the critical influence of micronutrients on the healing process of PUs. It suggests that a personalized approach to nutrition, which takes into account individual patient requirements and deficiencies, is likely to be more effective than a one-size-fits-all strategy in the management of these complex wounds.
immobility , nutrition , prealbumin , pressure injury , Pressure ulcers , trace elements , transferrin
Text of the article Перейти на текст статьи
Department of General Medical Practice with a Course of Evidence-Based Medicine, Astana Medical University, Astana, Kazakhstan
Nursing Department, Semey Medical University, Semey, Kazakhstan
School of Medicine, Nazarbayev University, Astana, Kazakhstan
School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
Medical Centre Hospital of Presidents Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Department of Infectious Diseases, Dermatovenereology and Immunology, Semey Medical University, Semey, Kazakhstan
Department of Molecular Biology and Medical Genetics Named After the Academician of the National Academy of Sciences Republic of Kazakhstan Raissov T.K, Semey Medical University, Semey, Kazakhstan
School of Medicine, Semey Medical University, Semey, Kazakhstan
Council for Nutritional and Environmental Medicine, Mo i Rana, Norway
Department of General Medical Practice with a Course of Evidence-Based Medicine
Nursing Department
School of Medicine
School of Sciences and Humanities
Medical Centre Hospital of Presidents Affairs Administration of the Republic of Kazakhstan
Department of Infectious Diseases
Department of Molecular Biology and Medical Genetics Named After the Academician of the National Academy of Sciences Republic of Kazakhstan Raissov T.K
School of Medicine
Council for Nutritional and Environmental Medicine
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026