Fluvoxamine may reverse the decrease in filtering capacity that occurs in acute kidney injury by increasing IL-10 and ACE expressions and preserving AQ-2, AQ-4, CL-5, and ZO-1 expressions
Karakuyu N.F. Camlica T. Asci H. Milletsever A. Ulusoy A. Gonuler F.M. Altuntas A.
July 2025Springer Science and Business Media Deutschland GmbH
Naunyn-Schmiedebergs Archives of Pharmacology
2025#398Issue 79021 - 9029 pp.
The kidneys have a regulatory role in many diseases with their diuresis function and capacity to maintain electrolyte balance. In case of extensive damage, the kidney’s filtration capacity is impaired and cannot fulfill its functions. Fluvoxamine (FLV), an antidepressant agent, has antioxidant and anti-inflammatory effects. This study aimed to investigate the protective effects of FLV against renal tissue damage in the lipopolysaccharide (LPS) induced systemic inflammation model. Thirty-two Wistar Albino rats were divided into four equal groups: control, LPS, LPS + FLV, and FLV alone. Six hours after LPS administration, rats were sacrificed and kidney tissues were removed. Histopathological examination of kidney tissues, immunohistochemical expression of the ACE-1, Cas-9, and interleukin-10 (IL-10), as well as spectrophotometric assessment of total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), urea, creatinine levels, and zonulin-1 (ZO-1), claudin-5 (CL-5), aquaporins 2 and 4 (AQ-2, AQ-4) were evaluated. TOS, OSI, urea, creatinine levels, and Cas-9 expressions were significantly increased, and TAS levels, ACE-1, IL-10, AQ-2, AQ-4, ZO-1, and CL-5 expressions significantly decreased in the LPS group compared with the control group. In addition, marked hyperemia, slight-to-moderate hemorrhages, and degeneration of the tubule epithelial cells were observed in kidney sections in the LPS group, in addition to the inflammatory cell infiltrations. FLV treatment significantly improved all these findings. FLV treatment ameliorates renal tissues against inflammatory scenes and protects renal function by enhancing IL-10 and ACE-1 expressions and preserving AQ-2, AQ-4, CL-5, and ZO-1 expressions.
Acute kidney injury , Inflammation , Oxidative stress , Rats
Text of the article Перейти на текст статьи
Faculty of Pharmacy, Department of Pharmacology, Suleyman Demirel University, Isparta, Kazakhstan
Health Research and Application Center, Suleyman Demirel University Research and Application Hospital, Isparta, Turkey
Faculty of Medicine, Department of Pharmacology, Suleyman Demirel University, Isparta, Kazakhstan
Faculty of Veterinary Medicine, Department of Pathology, Burdur Mehmet Akif Ersoy University, Burdur, Turkey
Institute of Science, Department of Bioengineering, Suleyman Demirel University, Isparta, Kazakhstan
Faculty of Medicine, Suleyman Demirel University, Isparta, Kazakhstan
Division of Nephrology, Faculty of Medicine, Department of Internal Medicine, Suleyman Demirel University, Isparta, Kazakhstan
Faculty of Pharmacy
Health Research and Application Center
Faculty of Medicine
Faculty of Veterinary Medicine
Institute of Science
Faculty of Medicine
Division of Nephrology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026