Investigation of Tannic Acid Crosslinked PVA/PEI-Based Hydrogels as Potential Wound Dressings with Self-Healing and High Antibacterial Properties
Karakuş N.R. Türk S. Guney Eskiler G. Syzdykbayev M. Appazov N.O. Özacar M.
November 2024Multidisciplinary Digital Publishing Institute (MDPI)
Gels
2024#10Issue 11
This study developed hydrogels containing different ratios of TA using polyvinyl alcohol (PVA) and polyethyleneimine (PEI) polymers crosslinked with tannic acid (TA) for the treatment of burn wounds. Various tests, such as scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), swelling, moisture retention, contact angle, tensile strength, the scratch test, antibacterial activity and the in vitro drug-release test, were applied to characterize the developed hydrogels. Additionally, the hydrogels were examined for cytotoxic properties and cell viability with the WST-1 test. TA improved both the self-healing properties of the hydrogels and showed antibacterial activity, while the added gentamicin (GEN) further increased the antibacterial activities of the hydrogels. The hydrogels exhibited good hydrophilic properties and high swelling capacity, moisture retention, and excellent antibacterial activity, especially to S. aureus. In addition, the swelling and drug-release kinetics of hydrogels were investigated, and while swelling of hydrogels obeyed the pseudo-second-order modeling, the drug release occurred in a diffusion-controlled manner according to the Higuchi and Korsmeyer–Peppas models. These results show that PVA/PEI-based hydrogels have promising potential for wound dressings with increased mechanical strength, swelling, moisture retention, self-healing, and antibacterial properties.
anti-freezing , antibacterial properties , drug release , hydrogel , self-healing , tannic acid
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Department of Biomedical Engineering, Institute of Natural Sciences, Sakarya University, Sakarya, 54187, Turkey
Biomaterials, Energy, Photocatalysis, Enzyme Technology, Nano & Advanced Materials, Additive Manufacturing, Environmental Applications and Sustainability Research & Development Group (BIOENAMS R & D Group), Sakarya University, Sakarya, 54050, Turkey
Biomedical, Magnetic and Semiconductor Materials Application and Research Center (BIMAS-RC), Sakarya University, Sakarya, 54187, Turkey
Department of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, 54100, Turkey
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis, Korkyt Ata Kyzylorda University, Aiteke bi Str., 29A, Kyzylorda, 120014, Kazakhstan
KazEcoChem LLP, D.Konaev Str. 12, Astana, 010010, Kazakhstan
Department of Chemistry, Faculty of Science, Sakarya University, Sakarya, 54050, Turkey
Department of Biomedical Engineering
Biomaterials
Biomedical
Department of Medical Biology
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis
KazEcoChem LLP
Department of Chemistry
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