Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus
Karabaeva R.Z. Vochshenkova T.A. Mussin N.M. Albayev R.K. Kaliyev A.A. Tamadon A.
2024Frontiers Media SA
Frontiers in Endocrinology
2024#15
Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses a significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly in histone modifications, DNA methylation, and microRNAs, play a pivotal role in unraveling the complex molecular underpinnings of blood pressure regulation. This review emphasizes the crucial interplay between epigenetic attributes and hypertension, shedding light on the prominence of DNA methylation, both globally and at the gene-specific level, in essential hypertension. Additionally, histone modifications, including acetylation and methylation, emerge as essential epigenetic markers linked to hypertension. Furthermore, microRNAs exert regulatory influence on blood pressure homeostasis, targeting key genes within the aldosterone and renin-angiotensin pathways. Understanding the intricate crosstalk between genetics and epigenetics in hypertension is particularly pertinent in the context of its interaction with T2DM, where hypertension serves as a notable risk factor for the development of CAD. These findings not only contribute to the comprehensive elucidation of essential hypertension but also offer promising avenues for innovative strategies in the prevention and treatment of cardiovascular complications, especially in the context of T2DM. Copyright
coronary artery disease , DNA methylation , epigenetics , genetic variation , histone , hypertension , modification , type 2 diabetes mellitus
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Gerontology Center, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department for Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Research and Development, PerciaVista R&D Co., Shiraz, Iran
Gerontology Center
General Surgery
Department for Natural Sciences
Department of Research and Development
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026