Effect of tirzepatide on blood pressure and lipids: A meta-analysis of randomized controlled trials

Kanbay M. Copur S. Siriopol D. Yildiz A.B. Gaipov A. van Raalte D.H. Tuttle K.R.
December 2023 John Wiley and Sons Inc

Diabetes, Obesity and Metabolism
2023 #25 Issue 12 3766 - 3778 pp.

Aim: To perform a meta-analysis to quantify the effect of tirzepatide on blood pressure and lipids. Methods: PubMed, Ovid/Medline, Web of Science, Scopus, Cochrane Library and CINAHL databases were screened and the randomized controlled trials evaluating the effects of tirzepatide on either blood pressure or lipid profiles were included. Results: Seven randomized controlled trials have investigated the effects of tirzepatide on blood pressure and lipid profiles. Regardless of the dose administered, tirzepatide resulted in significant decreases in systolic blood pressure of median −4.20 (95% confidence interval [CI] −5.17 to −3.23) mmHg for 5 mg, −5.34 (−6.31 to −4.37) mmHg for 10 mg, and −5.77 (−6.73 to −4.81) mmHg for 15 mg. At all three once-weekly doses, tirzepatide treatment resulted in significant decreases in total cholesterol levels: median −3.76% (95% CI −5.20% to −2.31%) for 5 mg; −4.63% (−6.07% to −3.19%) for 10 mg; and −5.93% (−7.36% to −4.49%) for 15 mg. Additionally, tirzepatide treatment led to increased high-density lipoprotein (HDL) cholesterol levels and decreased low-density lipoprotein (LDL) cholesterol and triglyceride levels. Conclusions: Tirzepatide induced clinically meaningful reductions in the levels of systolic and diastolic blood pressure, total cholesterol, LDL cholesterol and triglycerides, along with increases in the level of HDL cholesterol.

diastolic blood pressure , GIP/GLP-1 receptor agonist , HDL cholesterol , LDL cholesterol , systolic blood pressure , triglycerides

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Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey
Department of Medicine, Koc University School of Medicine, Istanbul, Turkey
Department of Nephrology, “Saint John the New” County Hospital, Stefan cel Mare University, Suceava, Romania
Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands
Division of Nephrology, University of Washington, Seattle, WA, United States
Providence Medical Research Center, Providence Inland Northwest Health, Spokane, WA, United States

Department of Medicine
Department of Medicine
Department of Nephrology
Department of Medicine
Diabetes Center
Division of Nephrology
Providence Medical Research Center

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