The Determination of the Biocompatibility of New Compositional Materials, including Carbamide-Containing Heterocycles of Anti-Adhesion Agents for Abdominal Surgery
Kanasheva N. Fedorishin D.A. Lyapunova M.V. Bukterov M.V. Kaidash O.A. Bakibaev A.A. Yerkassov R. Mashan T. Nesmeyanova R. Ivanov V.V. Udut E.V. Tuguldurova V.P. Salina M.V. Malkov V.S. Knyazev A.S.
February 2024Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2024#29Issue 4
Due to traumatic injuries, including those from surgical procedures, adhesions occur in over 50% of cases, necessitating exclusive surgical intervention for treatment. However, preventive measures can be implemented during abdominal organ surgeries. These measures involve creating a barrier around internal organs to forestall adhesion formation in the postoperative phase. Yet, the effectiveness of the artificial barrier relies on considerations of its biocompatibility and the avoidance of adverse effects on the body. This study explores the biocompatibility aspects, encompassing hemocompatibility, cytotoxicity, and antibacterial and antioxidant activities, as well as the adhesion of blood serum proteins and macrophages to the surface of new composite film materials. The materials, derived from the sodium salt of carboxymethylcellulose modified by glycoluril and allantoin, were investigated. The research reveals that film materials with a heterocyclic fragment exhibit biocompatibility comparable to commercially used samples in surgery. Notably, film samples developed with glycoluril outperform the effects of commercial samples in certain aspects.
anti-adhesion agents , barrier films , biocompatibility , carbamide-containing heterocycles , composite materials , surgery
Text of the article Перейти на текст статьи
Department of Chemistry, L.N. Gumilyov Eurasian National University, Astana, 010008, Kazakhstan
Faculty of Chemistry, National Research Tomsk State University, Tomsk, 634028, Russian Federation
Central Research Laboratory, Siberian State Medical University, Tomsk, 634050, Russian Federation
Department of Chemistry and Chemical Technologies, Faculty of Natural Sciences, Toraighyrov University, Pavlodar, 140008, Kazakhstan
Department of Chemistry
Faculty of Chemistry
Central Research Laboratory
Department of Chemistry and Chemical Technologies
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026