Antitumor potential of silver nanoparticles against lung cancer: current trends, scope and relevance
Kamboj A. Raj M. Kumar V. Upadhyay S.K. Singh M. Sharma A. Sharma A.K.
October 2025Springer Science and Business Media Deutschland GmbH
3 Biotech
2025#15Issue 10
Lung cancer continues to be a disease that is feared on a global scale due to its high mortality rates. The annual incidence of lung cancer is estimated to be 1.8 million, with approximately 1.6 million fatalities. Conventional treatment regimens are ineffective because they are unable to eradicate lung cancer stem cells (LCSCs). LCSCs are known to be highly resistant to treatment, induce relapse, strengthen metastasis, preserve tumorigenicity, and self-renewal. This demonstrates the necessity of a novel treatment modality that can specifically target lung cancer and its progenitor cells. Nanomaterials (NMs) handle unique challenges with outstanding solutions in a variety of industrial and scientific applications. Silver nanoparticles (AgNPs) are among the most commonly used NMs in drug delivery, medical diagnostics, energy harvesting devices, sensors, lubricants, and bioremediation. Notably, they have demonstrated strong antibacterial, anticancer, and antiviral capabilities in the biomedical sector. The literature analysis reveals a selective cytotoxic impact on cancer cells compared to healthy cells, highlighting its potential utility in cancer treatment and emphasizing the necessity to investigate the potential risk of their use to the environment and human health.
Antitumor potential , Lung cancer , Nanomedicine , Silver nanoparticles , Treatment
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Department of Bio-Science and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, Ambala, 133207, India
Department of Microbiology, International Medical School, UIB, Almaty, Kazakhstan
Department of Chemistry, Career Point University, Tikker-Kharwarian, Himachal Pradesh, Hamirpur, 176041, India
Centre for Nano-Science and Technology, Career Point University, Tikker-Kharwarian, Himachal Pradesh, Hamirpur, 176041, India
Department of Biotechnology, Amity University Punjab, Mohali, 140306, India
Department of Bio-Science and Technology
Department of Microbiology
Department of Chemistry
Centre for Nano-Science and Technology
Department of Biotechnology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026