Antimicrobial activity enhancement and acute toxicity lowering of benzamide through preparation of metal complexes
Kamalov S. Babaev B. Ibragimov A. Eshimbetov A. Ashurov J. Normamatov A. Tilyakov Z. Usmanov S. Tashpulatov J. Ibragimov B.
5 May 2024Elsevier B.V.
Journal of Molecular Structure
2024#1303
Two metal complexes [Mn(BZA)4Cl2] and [Cu2(BZA)2(CH3COO)4] (BZA - benzamide) have been synthesized and structurally characterized by element analysis, FT-IR, X-ray crystallography and Hirshfeld surface analysis. In silico (molecular docking) studies attest that biologically inactive compound BZA gains antimicrobial activity in result of metal complex formation. Antifungal activities of the metal complexes are higher than that of well-known compound fluconazole while antibacterial activities are comparable with biological action of standard drug levofloxacin. In vitro researches of antifungal activities confirm the results of the molecular docking studies whereas antibacterial activity of metal complexes is slightly higher than that of levofloxacin in silico activity. Moreover, in vivo determination of the metal complexes acute toxicity attests that LD50 of the initial compound (BZA ligand) is lowered more than two times in the metal complex, i.e. bioactivity and toxicity of BZA are enhanced through metal complex formation.
Acute toxicity , Antimicrobial activity , Hirshfeld surface analysis , Mn- and Cu-complexes , Molecular docking , X-ray structures
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National University of Uzbekistan named after Mirzo Ulugbek, 4 University St, Tashkent, 100174, Uzbekistan
Institute of General and Inorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan, M. Ulugbek Str, 77a, Tashkent, 100170, Uzbekistan
Institute of Bioorganic Chemistry of Academy of Sciences of the Republic of Uzbekistan, M. Ulugbek, Str, 83, Tashkent, 700125, Uzbekistan
Institute of Chemical Sciences of Kazakhstan NAS, Walikhanov str. 106, Almaty, 050010, Kazakhstan
Institute microbiology of the Academy of Sciences of the Republic of Uzbekistan, A.Kadyri str. 7B, 100128, Uzbekistan
National University of Uzbekistan named after Mirzo Ulugbek
Institute of General and Inorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan
Institute of Bioorganic Chemistry of Academy of Sciences of the Republic of Uzbekistan
Institute of Chemical Sciences of Kazakhstan NAS
Institute microbiology of the Academy of Sciences of the Republic of Uzbekistan
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