A Facile Method for Synthesizing Cobalt Oxide Nanoparticles to Create a Highly Sensitive Non-Enzyme Glucose Sensor
Kalkozova Z.K. Balgimbayeva U.A. Gabdullin M.T. Gritsenko L.V. Suo G. Abdullin K.A.
April 2025Multidisciplinary Digital Publishing Institute (MDPI)
Biosensors
2025#15Issue 4
In this study, an electrochemical non-enzymatic glucose sensor based on cobalt oxide was developed using a simple chemical bath deposition method. The as-synthesized material exhibited no significant sensitivity; the latter emerged only after subsequent electrochemical activation. To the best of our knowledge, this is the first report demonstrating the successful application of electrochemical activation to achieve enhanced sensitivity. An X-ray diffraction analysis confirmed that a single-phase Co2(OH)2(CO3) material was obtained immediately after synthesis, which was subsequently transformed into Co3O4 nanoparticles during electrochemical activation. SEM and TEM analyses revealed that the synthesized particles initially exhibited a nanorod structure, which evolved into a highly dispersed form after activation. The non-enzymatic glucose sensor based on the electrochemically activated material demonstrated excellent glucose sensitivity of 33,245 µA mM−1 cm−2 within the linear range of 0–0.5 mM, with a detection limit (LOD) of 5 µM. The starting material remained stable for over 12 months under ambient storage conditions and regained its high sensitivity following electrochemical activation.
chemical bath deposition , cobalt hydroxycarbonate , electrochemical sensor , enzyme free , glucose
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Institute of Applied Science & Information Technology, Shashkin Str. 40-48, Almaty, 050040, Kazakhstan
National Nanotechnology Laboratory of Open Type (NNLOT), Al-Farabi Kazakh National University, Al-Farabi Ave., 71, Almaty, 050040, Kazakhstan
School of Materials Science and Green Technology, Kazakh-British Technical University, Tole bi Street, 59, Almaty, 050000, Kazakhstan
General Physics Department, Institute of Energy and Mechanical Engineering, Satbayev University, Satpayev Str., 22, Almaty, 050013, Kazakhstan
School of Materials Science and Engineering, Shaanxi University of Science & Technology, Xi’an, 710021, China
Institute of Applied Science & Information Technology
National Nanotechnology Laboratory of Open Type (NNLOT)
School of Materials Science and Green Technology
General Physics Department
School of Materials Science and Engineering
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