Bacterial Colonization Incidence before and after Indwelling Double-J Ureteral Stents
Kaliyeva S. Simokhina N. Lavrinenko A. Zhussupova G. Zhunusov S. Semenikhina P. Bikbatyrova Y. Yelmagambetov B. Myasnikova Z.
July 2022MDPI
Antibiotics
2022#11Issue 7
The upper urinary tract stenting allows to restore the ureteral patency in various situations. However, one of the main disadvantages of stenting is bacterial contamination, which can be a source of persistent infections that hardly respond to antibiotic therapy. The aim of this study was to investigate the local spectrum of bacterial pathogens and their susceptibility to antibiotics in order to optimize antibacterial therapy after upper urinary tract stenting. A prospective observational study was conducted in which 140 urine samples were examined (70 before stenting and 70 after stenting). Bacterial growth was detected in 37 patients (52.8%) before stenting and in 43 patients (61.4%) after stenting. E. coli (13 (28.8%)) and Streptococcus spp. (8 (17.6%)) strains were more commonly detected before stenting; P. aeruginosa (15 (31.2%)) and E. coli (8 (16.6%)) were usually revealed after stenting. The proportion of P. aeruginosa strains after stenting grew from 4.4% up to 31.2%. E. coli strains were resistant to ampicillin (92.3% before and 100% after stenting). Three strains of E. coli (23.1%) and six strains of P. aeruginosa (40%) were multidrug-resistant. Determination of the bacterial sensitivity to antibiotics and identification of antibiotic-resistant forms of bacteria is a factor in reducing the risk of complications and optimizing antibiotic therapy during the upper urinary tract stenting.
antibiotic stewardship , antibiotic susceptibility , antibiotics , antimicrobial resistance , stenting , upper urinary tract , urinary tract infections
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Department of Clinical Pharmacology and Evidence-Based Medicine, NCJSC Karaganda Medical University, Karaganda, 100000, Kazakhstan
Scientific Research Laboratory, NCJSC Karaganda Medical University, Karaganda, 100000, Kazakhstan
National Center for Rational Use of Medicines, Nur-Sultan, 010000, Kazakhstan
Department of Surgery Diseases, NCJSC Karaganda Medical University, Karaganda, 100000, Kazakhstan
Neurology, Psychiatry and Rehabilitation Department, NCJSC Karaganda Medical University, Karaganda, 100000, Kazakhstan
“SANAT” National Education Development Science Center, Nur-Sultan, 010000, Kazakhstan
Department of Clinical Pharmacology and Evidence-Based Medicine
Scientific Research Laboratory
National Center for Rational Use of Medicines
Department of Surgery Diseases
Neurology
“SANAT” National Education Development Science Center
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