Genome-Wide Tool for Sensitive de novo Identification and Visualisation of Interspersed and Tandem Repeats
Kalendar R. Kairov U.
January-December 2024SAGE Publications Inc.
Bioinformatics and Biology Insights
2024#18
Genomic repeats are functionally ubiquitous structural units found in all genomes. Studying these repeats of different origins is essential for understanding the evolution and adaptation of a given organism. These repeating patterns have manifold signatures and structures with varying degrees of homology, making their identification challenging. To address this challenge, we developed a new algorithm and software that can rapidly and accurately detect any repeated sequences de novo with varying degrees of homology in genomic sequences in interspersed or clustered repeats. Numerous forms of repeated sequences and complex patterns can be identified, even for complex sequence variants and implicit or mixed types of repeat blocks. Direct and inverted-repeat elements, perfect and imperfect microsatellite repeats, and any short or long tandem repeat belonging to a wide range of higher-order repeat structures of telomeres or large satellite sequences can be detected. By combining precision and versatility, our tool contributes significantly to elucidating the intricate landscape of genomic repeats.
Direct and inverted repeats , interspersed elements , minisatellite repeats , mobile genetic elements , repeats analysis tool , tandem repeats
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Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
Laboratory of Bioinformatics and Systems Biology, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
Helsinki Institute of Life Science (HiLIFE)
Laboratory of Bioinformatics and Systems Biology
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