Design of New Daunorubicin Derivatives with High Cytotoxic Potential
Kalashnikova A.A. Toibazarova A.B. Artyushin O.I. Anikina L.V. Globa A.A. Klemenkova Z.S. Andreev M.V. Radchenko E.V. Palyulin V.A. Aleksandrova Y.R. Syzdykbayev M.I. Appazov N.O. Chubarev V.N. Neganova M.E. Brel V.K.
February 2025Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
2025#26Issue 3
Chemotherapy with anthracycline antibiotics is a common method of treating tumors of various etiologies. To create more highly effective cytostatics based on daunorubicin, we used the method of reductive amination using polyalkoxybenzaldehydes. The obtained derivatives of the anthracycline structure have much greater cytotoxicity compared to daunorubicin due to increased affinity for DNA, the ability to disrupt the cell cycle, and their inhibition of the glycolysis process, which is confirmed by data from extensive biological studies and the results of molecular modeling.
anthracycline antibiotics , cell cycle , chemotherapy , cytotoxicity , daunorubicin , glycolysis
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Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow, 119991, Russian Federation
Laboratory of Engineering Profile, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda, 120014, Kazakhstan
Institute of Physiologically Active Compounds of the FSBIS of the Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of the RAS, 1 Severnyi Proezd, Chernogolovka, 142432, Russian Federation
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, Moscow, 119991, Russian Federation
Department of Biology, Geography and Chemistry, Laboratory of Engineering Profile, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda, 120014, Kazakhstan
Laboratory of Engineering Profile, Department of Engineering Technology, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda, 120014, Kazakhstan
CNEC” LLP, Dariger Ali Lane, 2, Kyzylorda, 120001, Kazakhstan
Department of Pharmacology, The Institute of Pharmacy Named after A.P. Nelyubin, Sechenov University, Trubetskaya St., 8-2, Moscow, 119991, Russian Federation
Nesmeyanov Institute of Organoelement Compounds
Laboratory of Engineering Profile
Institute of Physiologically Active Compounds of the FSBIS of the Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of the RAS
Department of Chemistry
Department of Biology
Laboratory of Engineering Profile
CNEC” LLP
Department of Pharmacology
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