Pipelle endometrial biopsy for abnormal uterine bleeding: do patient’s pain and anxiety really impact on sampling success rate?
Kaiyrlykyzy A. Linkov F. Foster F. Bapayeva G. Ukybassova T. Aimagambetova G. Kenbayeva K. Ibrayimov B. Lyasova A. Terzic M.
December 2021BioMed Central Ltd
BMC Womens Health
2021#21Issue 1
Background: Pipelle endometrial biopsy is vital for the early diagnostics of endometrial pathology and is performed in outpatient setting in minimally invasive manner. One of the reported disadvantages of sampling with Pipelle curette is failure to collect enough tissue for histological analysis. The role of psychological factors such as anxiety and pain sensitivity in obtaining adequate samples is not well known. The studys objective was to explore whether there is relationship between severe pain, anxiety, and the rate of Pipelle failure. Methods: Study included 158 women with median age of 42 who underwent Pipelle endometrial biopsy at Clinical Academic Department of Women’s Health of the University Medical Center (UMC), Nur-Sultan City, Kazakhstan with an abnormal uterine bleeding from June 2019 to April 2021. Women were asked to fill survey on pain, anxiety before, during and after the procedure. Results: 3.8%, 15.19% and 4.43% of women reported severe pain and 39.24%, 34.18% and 14.56% of women reported severe anxiety prior, during and after procedure, respectively. Women who experienced severe pain during procedure tend to be more anxious during procedure (p = 0.0001) and have higher number of sampling attempts (p = 0.0040). Pain level was higher among patients sampled by the junior OB/GYN specialist (p < 0.0001). We found no differences in Pipelle biopsy success rates in relationship to baseline, during and postprocedural pain and anxiety scores. Conclusion: Anxiety during procedure performance was significantly associated with severe pain during the procedure but did not represent a key element for the success of Pipelle biopsy.
Anxiety , Endometrial sampling , Pain , Pipelle endometrial biopsy , Pipelle failure , Pipelle sampling
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National Laboratory of Astana, Nazarbayev University, Kabanbay Batyr Street, 53, Nur-Sultan, 010000, Kazakhstan
Department of Health Administration and Public Health, John G. Rangos, Sr. School of Health Sciences Duquesne University, 600 Grant St, Pittsburgh, 15282, PA, United States
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, 15213, PA, United States
Department of Medicine, Nazarbayev University School of Medicine, Zhanybek-Kerey Khans Street, 5/1, Nur-Sultan, 010000, Kazakhstan
Clinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, Turan Ave. 32, Nur-Sultan, 010000, Kazakhstan
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Zhanybek-Kerey Khans Street, 5/1, Nur-Sultan, 010000, Kazakhstan
Clinical Academic Department of Laboratory Medicine, Pathology and Genetics, University Medical Center, Republican Diagnostic Center, 2 Syganaq Street, Nur-Sultan, 010000, Kazakhstan
Pathology Bureau of Nur-Sultan City Administration, Zhansugirov Street, 1, Nur-Sultan, 010000, Kazakhstan
National Laboratory of Astana
Department of Health Administration and Public Health
Department of Obstetrics
Department of Medicine
Clinical Academic Department of Women’s Health
Department of Biomedical Sciences
Clinical Academic Department of Laboratory Medicine
Pathology Bureau of Nur-Sultan City Administration
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