Whole-genome sequencing data of Kazakh individuals
Kairov U. Molkenov A. Rakhimova S. Kozhamkulov U. Sharip A. Karabayev D. Daniyarov A. H.Lee J. D.Terwilliger J. Akilzhanova A. Zhumadilov Z.
December 2021BioMed Central Ltd
BMC Research Notes
2021#14Issue 1
Objectives: Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today is the multi-ethnic country with the dominant Kazakh ethnic group. We sequenced and analyzed the whole-genomes of five ethnic healthy Kazakh individuals with high coverage using next-generation sequencing platform. This whole-genome sequence data of healthy Kazakh individuals can be a valuable reference for biomedical studies investigating disease associations and population-wide genomic studies of ethnically diverse Central Asian region. Data description: Blood samples have been collected from five ethnic healthy Kazakh individuals living in Kazakhstan. The genomic DNA was extracted from blood and sequenced. Sequencing was performed on Illumina HiSeq2000 next-generation sequencing platform. We sequenced and analyzed the whole-genomes of ethnic Kazakh individuals with the coverage ranging from 26 to 32X. Ranging from 98.85 to 99.58% base pairs were totally mapped and aligned on the human reference genome GRCh37 hg19. Het/Hom and Ts/Tv ratios for each whole genome ranged from 1.35 to 1.49 and from 2.07 to 2.08, respectively. Sequencing data are available in the National Center for Biotechnology Information SRA database under the accession number PRJNA374772.
Bioinformatics analysis , Biomedical research , Genome annotation , Kazakh ethnicity , Kazakhstan , Next-generation sequencing , Population genomics , Whole genome
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Laboratory of Bioinformatics and Systems Biology, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
Laboratory of Genomic and Personalized Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
Columbia University, New York, United States
School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
Laboratory of Bioinformatics and Systems Biology
Laboratory of Genomic and Personalized Medicine
Columbia University
School of Medicine
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