Immune polychemotherapy regimen choice in B-cell non-Hodgkin lymphoma of high and low malignancy based on the identification of the mutational c-myc and BCL 2 genes
Kaidarova D.R. Karakulov R.K. Gabbasova S.T. Karazhanova M.K. Lyubko S.A.
May 2022Collegium Medicum University of Warmia and Mazury
Polish Annals of Medicine
2022#29Issue 131 - 37 pp.
Introduction: The relevance of research is conditioned by the study of the gene expression profile for the identification of molecular subgroups of non-Hodgkin B-cell lymphomas (NHBCLs) in haematology. A i m: The aim of this research was to study the gene expression profile with the identification of molecular subgroups in patients with NHBCLs for personalised treatment. Ma t e r i a l a nd me t ho ds: This paper is aimed at analysing the frequency and role of expression of c-myc, B-cell lymphoma 2 (BCL 2) proteins and the Ki 67 proliferative index in patients with NHBCLs and conducting personalised therapy to improve the immediate effectiveness and immediate treatment results. Re s ul t s a nd di s c us s i o n: The paper presents the results of the use of high-dose polychemotherapy (PCT) in 9 patients out of 80 with NHBCL during co-expression of the c-myc, BCL 2 mutational gene and with high values of the Ki 67 proliferative index. High-dose chemotherapy (HDCT) was performed according to the R+HyperCVAD scheme (6 courses) and hematopoietic stem cell (HSC) autotransplantation improved the immediate effectiveness of therapy, with a complete remission rate of 80% and an event-free survival of 28 months. Co nc l us i o ns: The study of molecular genetic characteristics in 80 patients with NHBCLs revealed co-expression of the c-myc and BCL 2 mutational gene in 9 out of 80 patients, and they differed in the aggressive course, ‘poor’ response to therapy, which predetermined the use of high-dose PCT with transplantation of autologous stem cells.
B-cell lymphoma , BCL 2 , c-myc mutation gene , High-dose polychemotherapy with HSC autotransplantation
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Department of Management, Kazakh Research Institute of Oncology and Radiology, Almaty, Kazakhstan
Center for Hemoblastosis and Bone Marrow Transplantation, Kazakh Research Institute of Oncology and Radiology, Almaty, Kazakhstan
Center for Hematology and Bone Marrow Transplantation, Kazakh Research Institute of Oncology and Radiology, Almaty, Kazakhstan
Laboratory of Cytogenetic and Moleculear Cytogenetic, Research Institute of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan
Center for Morphological Research, Kazakh Research Institute of Oncology and Radiology, Almaty, Kazakhstan
Department of Management
Center for Hemoblastosis and Bone Marrow Transplantation
Center for Hematology and Bone Marrow Transplantation
Laboratory of Cytogenetic and Moleculear Cytogenetic
Center for Morphological Research
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