The role of fetal pancreatic islet cell transplantation in the treatment of type 2 diabetes mellitus
Kaibagarova I. Saparbaev S. Aringazina R. Zhumabaev M. Nurgaliyeva Z.
December 2024Springer Science and Business Media Deutschland GmbH
Journal of Diabetes and Metabolic Disorders
2024#23Issue 21949 - 1957 pp.
Objectives: Diabetes mellitus has a negative impact on patients’ lives and is a significant medical and social problem. Due to the high prevalence of diabetes mellitus, shortage of donor materials, immune rejection of the pancreas and limited efficacy of existing treatment methods, the study of promising and more effective approaches to the treatment of this disease, such as transplantation of fetal pancreatic islet cells, becomes relevant. The aim of the study is to determine the efficacy and necessity of fetal pancreatic islet cell transplantation in the treatment of type 2 diabetes mellitus. Methods: The study was carried out with the help of analytical-synthetic method, literature review and analysis of medical databases corresponding to the topic of work, clinical and experimental studies conducted by other authors were considered. Results: As a result of this work, it was found that the use of fetal stem cell transplantation is an effective method in the treatment of diabetes. Studies confirm that this method reduces hyperglycaemia and NOMA index, increases c-peptide values without serious side effects on the background of treatment. Conclusions: Fetal islet cells have advantages in cell culture, relatively low immunogenicity, effective engraftment, although they may produce less insulin relative to adult somatic stem cells. Transplanted islet cells are able to replace and renew the function of the recipient’s own pancreatic β-cells, and prevent their destruction. Fetal pancreatic islet cell transplantation is a promising treatment option for type 2 diabetes that can complement or replace existing therapies, improving patients’ glucose control.
Fetal pancreatic islet cells , Hyperglycaemia , Insulin resistance , Pancreatic fetal stem cell transplantation , Type 2 diabetes mellitus
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Department of Pharmacology, West Kazakhstan Marat Ospanov Medical University, 68 Maresyev Str, Aktobe, 030012, Kazakhstan
Medical Center Al-Jami, 23 Mailin Str, Astana, 010000, Kazakhstan
Department of Internal Diseases No. 1, West Kazakhstan Marat Ospanov Medical University, 68 Maresyev Str., Aktobe, 030012, Kazakhstan
Department of Surgical Diseases No. 1, West Kazakhstan Marat Ospanov Medical University, 68 Maresyev Str., Aktobe, 030012, Kazakhstan
Department of Pharmacology
Medical Center Al-Jami
Department of Internal Diseases No. 1
Department of Surgical Diseases No. 1
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