Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites: Evaluation of Their Enhanced Anticancer Activity toward Human Cancer Cell Lines
Kadiyala N.K. Mandal B.K. Reddy L.V.K. Barnes C.H.W. De Los Santos Valladares L. Sen D.
17 January 2023American Chemical Society
ACS Omega
2023#8Issue 22406 - 2420 pp.
This study mainly deals with an effective one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed zirconium oxide nanoparticles on the flattened rough surface of reduced graphene oxide (ZrO2/rGO NCs) using the aqueous leaf extract of Andrographis paniculata. After obtaining detailed information on the preparation and characterization, the anticancer activity of the synthesized ZrO2/rGO nanocrystals (NCs) was evaluated on two human cancer cell lines (A549 and HCT116) along with one normal human cell line (hMSC). The 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide assays revealed that ZrO2/rGO NCs exhibited a dose-dependent cytotoxicity pattern. The cell viability (%) drastically decreases up to 96− 98% after exposure to an optimal concentration of 10 ppm nanocomposites. Analysis of both the reactive oxygen species generation and the Annexin V-FTIC staining assays reveal that ZrO2/rGO NCs have the ability to induce apoptosis in A549 and HCT116 cell lines. Thus, the green synthesis of ZrO2/rGO NCs shows potential in developing efficient therapeutic agents for cancer therapy.(Figure Presented).
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Trace Elements Speciation Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore, 632014, India
Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, CB3 0HE, United Kingdom
Faculty of Physics and Technology, L.N. Gumilyov Euroasian National University, Nur-Sultan, 010000, Kazakhstan
Laboratorio de Cerámicos y Nanomateriales, Facultad de Ciencias Físicas, Universidad Nacional Mayor de San Marcos, Lima, 14-0149, Peru
Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT), Vellore, 632014, India
Trace Elements Speciation Research Laboratory
Cavendish Laboratory
Faculty of Physics and Technology
Laboratorio de Cerámicos y Nanomateriales
Cellular and Molecular Therapeutics Laboratory
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