Relation between Guillain-Barré syndrome and Covid-19: Case-Series

Jumagaliyeva M.B. Ayaganov D.N. Abdelazim I.A. Saparbayev S.S. Tuychibaeva N.M. Kurmambayev Y.J.
2023 Carol Davila University Press

Journal of Medicine and Life
2023 #16 Issue 9 1433 - 1435 pp.

Approximately two-thirds of the Guillain-Barré syndrome (GBS) cases are preceded by upper respiratory tract infection or enteritis. There has been previous documentation of a clear association between Covid-19 and GBS. Covid-19 can affect the nervous tissue either through direct damage or through triggering a host immune response with subsequent development of autoimmune diseases such as GBS. Covid-19 can affect the host`s immune system through the activation and interaction of the T-and B-lymphocytes with subsequent production of antibodies that cross-react with the gangliosides. Depending on the nature of the neuronal autoimmune destruction, the affected individual may have either a demyelinating or axonal subtype of GBS. These subtypes differ not only in symptoms but also in the likelihood of recovery. This report presents two cases of GBS that developed after the respiratory symptoms of Covid-19. Their neurological features indicated demyelination, axonal damage, irritation of spinal nerve roots, and impaired sensory and motor transmission with additional facial nerve palsy in the second-studied case. This case report highlights the relationship between GBS and Covid-19 infection.

Covid-19 , GBS , Guillain-Barré syndrome

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Department of Neurology, Psychiatry and Narcology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Neurology, Psychology and Psychotherapy, Tashkent Medical Academy, Tashkent, Uzbekistan

Department of Neurology
Department of Obstetrics and Gynecology
Department of Normal Physiology
Department of Neurology

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