A novel mouse wound model for scar tissue formation in abdominal muscle wall

Jimi S. Saparov A. Koizumi S. Miyazaki M. Takagi S.
2021 Japanese Society of Veterinary Science

Journal of Veterinary Medical Science
2021 #83 Issue 12 1933 - 1942 pp.

Hypertrophic scars found on the human body rarely develop in experimental animals, possibly due to their looser skin structure. This makes it difficult to understand the genesis of scar lesions. Therefore, appropriate animal models are urgently needed. In this study, we established a novel experimental model of a scar-forming wound by resecting a small portion of the abdominal muscle wall on the lower center of the abdomen in C57BL/6N mice, which are exposed to contractive forces by the surrounding muscle tissue. As a low-tension control, a back skin excision model was used with a splint fixed onto the excised skin edge, and granulation tissue formed on the muscle fascia supported by the back skeleton. One week after the resection, initial healing reactions, such as fibroblast proliferation, occurred in both models. However, after 21 days, lesions with collagen-rich granulation tissues, which were also accompanied by multiple nodular/spherical-like structures, developed only in the abdominal wall model. These lesions were analogous to scar lesions in humans. Therefore, the animal model developed in this study is unique in that fibrous scar tissues form under physiological conditions without using any artificial factors and is valuable for studying the pathogenesis and preclinical treatment of scar lesions.

Animal model , Fibrosis , Granulation tissue , Scarring , Wound healing

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Central Lab for Pathology and Morphology, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan
Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
R&D Center, Nitta Gelatin Inc., Osaka, 581-0024, Japan
Department of Pharmacy, Fukuoka University Chikushi Hospital, Fukuoka, 818-0067, Japan
Department of Plastic Reconstructive and aesthetic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan

Central Lab for Pathology and Morphology
Department of Medicine
R&D Center
Department of Pharmacy
Department of Plastic Reconstructive and aesthetic Surgery

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