Ultrasensitive and simultaneous detection for bioactive compounds of baicalein and chrysin in traditional Chinese medicine via Bi2MoO6-MWCNTs based sensing platform
Jiang Y. Sima Y. Alomar T.S. AlMasoud N. El-Bahy Z.M. Feng J. Wan K. Toktarbay Z. He Q. Ding J. Wang J. Wang W.
December 2024Springer Science and Business Media B.V.
Advanced Composites and Hybrid Materials
2024#7Issue 6
The pursuit of rapid and sensitive detection methods for bioactive compounds in traditional Chinese medicine (TCM) is a continuous quest in the field of natural product chemistry. Herein, we report the development of a novel nanocomposite material comprising bismuth molybdate (Bi2MoO6) and multi-walled carbon nanotubes (MWCNTs), which has been successfully applied to the ultrasensitive and simultaneous detection of the bioactive flavonoids baicalein and chrysin. These compounds, known for their potent anticancer and antioxidant properties, are prevalent in TCM and nutraceuticals. The Bi2MoO6-MWCNTs nanocomposite was meticulously characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV), revealing its structural and functional attributes. The optimized electrochemical sensor, based on a glassy carbon electrode modified with the nanocomposite, demonstrated remarkable sensitivity with a linear response range of 0.001–5.0 μmol·L−1 for baicalein and 0.007–3.0 μmol·L−1 for chrysin, alongside impressively low detection limits of 0.2 nmol·L−1 and 1.4 nmol·L−1, respectively. The sensor’s performance was further validated through its application in the analysis of human serum and Scutellaria baicalensis extracts, showcasing its robust repeatability, selectivity, and stability. This work not only advances the field of TCM analysis but also opens new horizons for the integration of hollow bimetallic oxides with carbon-based materials in electrochemical sensing, offering a strategic approach to the rapid assessment of bioactive constituents in complex matrices.
Baicalein , Bismuth molybdate , Chrysin , Electrochemical sensor , Traditional Chinese medicine , Ultrasensitive detection
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School of Life Science and Chemistry, Hunan University of Technology, Zhuzhou, 412007, China
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Hunan, Changsha, 410082, China
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia
Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt
Institute of Ecological Problems, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty, 050040, Kazakhstan
Laboratory of Engineering Profile, Satbayev University, Satbayev St. 22a, Almaty, 050013, Kazakhstan
Zhuzhou People’s Hospital, Zhuzhou, 412001, China
Northwest Institute for Nonferrous Metal Research, Xi’an, 710016, China
School of Life Science and Chemistry
Molecular Science and Biomedicine Laboratory (MBL)
Department of Chemistry
Department of Chemistry
Institute of Ecological Problems
Laboratory of Engineering Profile
Zhuzhou People’s Hospital
Northwest Institute for Nonferrous Metal Research
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