The Roles of myomiRs in the Pathogenesis of Sarcopenia: From Literature to In Silico Analysis
Jia H. Kaster N. Khan R. Ayari-Akkari A.
February 2026Springer
Molecular Biotechnology
2026#68Issue 2367 - 385 pp.
Senile sarcopenia is a condition of age-associated muscular disorder and is a significant health issue around the world. In the current review, we curated the information from the NCBI, PubMed, and Google Scholar literature and explored the non-genetic and genetic causes of senile sarcopenia. Interestingly, the myomiRs such as miR-1, miR-206, miR-133a, miR-133b, miR-208b, and miR-499 are skeletal muscle’s critical structural and functional regulators. However, very scattered information is available regarding the roles of myomiRs in different skeletal muscle phenotypes through a diverse list of known target genes. Therefore, these pieces of information must be organized to focus on the conserved target genes and comparable effects of the myomiRs in regulating senile sarcopenia. Hence, in the present review, the roles of pathogenetic factors in regulating senile sarcopenia were highlighted. The literature was further curated for the roles of myomiRs such as hsa-miR-1-3p/206, hsa-miR-27-3p, hsa-miR-146-5p, and hsa-miR-499-5p and their target genes. Additionally, we used different bioinformatics tools and predicted target genes of the myomiRs and found the most critical target genes, shared pathways, and their standard functions in regulating muscle structure and functions. The information gathered in the current review will help the researchers to explore their possible therapeutic potential, especially the use of the myomiRs for the treatment of senile sarcopenia.
Causes of sarcopenia , MiRNAs in sarcopenia , Muscular atrophy , MyomiRs , Sarcopenia
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Medical College of Xuchang University, No.1389, Xufan Road, Henan, Xuchang, 461000, China
College of Animal Science and Technology, Northwest A & F University, Yangling, 712100, China
Department of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, Pakistan
Faculty of Veterinary and Livestock Technology, S. Seifullin Kazakh Agro Technical University, Astana, Kazakhstan
Biology Department, College of Science, King Khalid University, P.O. Box 960, Abha, Saudi Arabia
Medical College of Xuchang University
College of Animal Science and Technology
Department of Livestock Management
Faculty of Veterinary and Livestock Technology
Biology Department
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026